How does Tezspire differ from other biologics for asthma?

Hello,

Welcome to icliniq.com.

I have read your query and understand your concerns.

Thank you for your question. I understand how exhausting and frustrating it can be to live with severe eosinophilic asthma, especially when frequent use of oral steroids impacts both your health and overall quality of life.

Tezspire (Tezepelumab) is a newer biologic treatment that offers a promising option for patients like you who have not responded well to conventional inhalers or who require repeated courses of steroids.

Here is the list of causes-

• High eosinophil-driven inflammation in the airways.

• Possible inadequate response to inhaled corticosteroids and long-acting bronchodilators.

• Airway remodeling and chronic inflammation.

• Environmental or allergic triggers.

I suggest that you do the following investigations:

• Blood eosinophil count.

• Serum IgE levels.

• Spirometry or pulmonary function test (PFT).

• FeNO (fractional exhaled nitric oxide) testing (if available).

• Chest imaging (if not recently done).

• Allergy testing (optional, to identify triggers).

Differential diagnosis includes -

• Non-eosinophilic asthma.

• Chronic obstructive pulmonary disease (COPD).

• Allergic bronchopulmonary aspergillosis (ABPA).

• Vocal cord dysfunction.

• Cardiac-related shortness of breath.

The probable diagnosis is severe eosinophilic asthma not adequately controlled with standard therapy, likely steroid-dependent.

I recommend the following treatment plan -

1. Initiate Tezspire (Tezepelumab), a monoclonal antibody administered once monthly via injection. Unlike some other biologics (for example, Mepolizumab, Benralizumab) that specifically target eosinophils, Tezspire blocks TSLP (thymic stromal lymphopoietin), an upstream inflammatory signal, making it effective in a broader range of asthma types, including eosinophilic and non-eosinophilic asthma.

2. Expected response: Some patients begin to notice improvement in four to six weeks, with better control over time (three to six months). It has been shown to reduce asthma attacks, ER (emergency room) visits, and steroid use significantly.

3. Monitor closely for improvement in nighttime symptoms, inhaler use, and lung function over the next one to three months.

4. Continue controller therapy (inhaled corticosteroids, LABAs (long-acting beta-agonists)) during initial treatment unless advised otherwise by your doctor.

5. Taper oral steroids gradually if symptoms improve and under guidance.

6. Vaccination check: Consider screening for latent infections (for example, tuberculosis) before starting biologics, as per protocol.

I hope this helps.

Thank you.