How effective is Tezpire in severe asthma?

Question

Hello doctor,

I suffer from moderate to severe asthma, and my current treatment regimen is proving ineffective. Over the past year, I have been hospitalized twice due to exacerbations and rely on my rescue inhaler multiple times each week. My physician has introduced me to a new medication called Tezspire. As I have never used a biologic treatment before, I am uncertain about what to anticipate. How does Tezspire (Tezepelumab) compare to other asthma biologics such as Xolair or Dupixent? What is the frequency of administration, and can one expect to experience relief quickly? I have concerns regarding potential side effects and whether this medication will be a lifelong necessity. Can it genuinely reduce the frequency of asthma attacks?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Tezspire (Tezepelumab, a monoclonal antibody used in asthma treatment) is a newly approved medication designed to treat severe asthma that does not respond to traditional treatments such as steroids and inhalers. Following clinical studies, it has been authorized for use in individuals aged 12 to 80 years.

Is Tezspire different from other asthma injections like Xolair (omalizumab, a drug for severe asthma) or Dupixent (dupilumab, an asthma drug)? Yes, it has a slightly different mechanism of action, making it distinct from these other treatments.

How frequently is it administered, and can you expect to feel better quickly? The frequency of administration is determined by your healthcare provider. Typically, Tezspire is given as a weekly injection, although in some cases, it may be administered monthly. It is not intended for indefinite use; treatment usually lasts for one to two years before being discontinued. Patients often notice stable improvement by the fourth or fifth week of treatment.

Concerned about potential side effects and whether this will be a lifelong requirement. Can it help reduce asthma attacks? As previously mentioned, Tezspire is not intended for lifelong use; it is administered for a limited period. Many patients have reported significant improvements, indicating that it can indeed help reduce the frequency of severe asthma attacks.

However, it is important to be aware of potential side effects. Common complaints among patients receiving Tezspire include frequent sore throat, joint pain, and headaches, which may persist during the course of treatment.

I hope this information helps you.

Feel free to ask further queries.

Thank you.