Are there any side effects of Tezepelumab ?

Question

Hello doctor,

I have severe eosinophilic asthma, and my pulmonologist started me on Tezspire (Tezepelumab, a monoclonal antibody) two months ago. I am still experiencing some mild flare‑ups.

How long does it usually take to see the full benefits of Tezspire?
Does Tezspire reduce the long‑term need for corticosteroids?
Is it safe to take Tezspire alongside allergy shots or biologics such as Dupilumab (Interleukin‑4 [IL‑4] and Interleukin‑13 [IL‑13] Inhibitor)?
Can Tezspire help with nasal polyps as well?
If I miss a dose by a few days, should I administer it late or skip it entirely?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Studies on effectiveness.

Yes, multiple studies in patients aged 12 to 80 years have demonstrated significant improvements in severe asthma symptoms, regardless of age.

Duration of treatment.

Tezspire (Tezepelumab, a monoclonal antibody) is not necessarily indefinite. Typically, clinicians prescribe it for one year and then reassess. Depending on your response, they may shorten or extend the course, often aiming for one to two years of treatment.

Common side effects.

When starting Tezspire, you may experience:

Pharyngitis (sore throat).
Arthralgia (joint pain).
Back pain.
Injection‑site reactions (redness, swelling).
Headaches.

4. Inhaler use.

Tezspire does not replace your inhalers or other controller medications. It is an add‑on therapy. As you improve, your physician will adjust your existing medication doses and schedules.

5. Time to onset of effect.

Most patients notice a stable improvement by 4 to 5 weeks after initiating weekly injections, with full benefits often evident by the end of the second month.

6. Concomitant allergy shots or biologics.

It is best to administer elective injections (e.g., allergy shots, Dupilumab [Interleukin-4 and Interleukin-13 Inhibitor]) on separate days. In emergencies, your treating physician will decide the appropriate schedule.

7. Effect on nasal polyps.

Although there are no dedicated studies, Tezspire’s immune‑modulating action may positively affect nasal polyps when managed alongside standard therapies.

8. Missed doses

Do not skip doses. If you miss an injection by a few days, receive it as soon as possible and then continue on your regular schedule. Occasional delays are acceptable but should not become routine, as they may prolong your overall treatment duration.

I hope this clarifies your concerns. Please follow up if you have further questions.

Thank you.