What are the side effects of Tezspire?

Question

Hello doctor,

I have been using Tezspire for my severe asthma for the past eight weeks, as you prescribed. Initially, I experienced a significant improvement in my pulmonary function tests, which allowed me to stop taking daily prednisone. However, in the last ten days, I have developed troubling symptoms, including severe migraine-like headaches, palpitations (with a heart rate of 135 at rest), and a widespread urticarial rash on my trunk and extremities. My spirometry results have also worsened, with my FEV1 decreasing from 78 to 62 percent. I have encountered paradoxical bronchoconstriction following my most recent subcutaneous injection.

The specialty pharmacy has cautioned me about the potential for anaphylaxis, but I am uncertain whether these symptoms are typical side effects or indicative of developing antibodies to the monoclonal antibody. The cost-benefit analysis is perplexing; while Tezspire has managed my refractory asthma more effectively than any other treatment, these new symptoms are alarming.

Should I consider premedication before my next dose, or should I explore switching to another biologic, such as Nucala? My next scheduled injection is in three days, and I am hesitant to proceed.

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

The most frequently reported side effects of Tezspire (tezepelumab, a monoclonal antibody) include sore throat, as well as joint and back pain. However, these are not the only potential side effects; they are simply the ones that have been documented.

It is advisable to continue using another bronchodilator.

Tezspire is a prescription medication intended for use alongside other asthma treatments for the ongoing management of severe asthma in individuals aged 12 and older whose condition remains uncontrolled with their current medications. Tezspire aids in preventing severe asthma attacks (exacerbations) and can enhance your breathing capacity. It is important to note that this medicine is not designed for the treatment of sudden breathing difficulties. If your asthma does not improve or worsens after starting Tezspire, inform your healthcare provider. The safety and efficacy of Tezspire in children under 12 years of age have not been established.

Therefore, it is essential to continue taking your existing asthma medications in conjunction with Tezspire. This medication is intended solely to enhance the effectiveness of your asthma treatment alongside your current regimen.

Since asthma exacerbations can mimic the symptoms of an infection, it is beneficial to manage and treat these episodes with bronchodilators.

I hope this information helps you.

Feel free to ask further queries.

Thank you.