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Does Topiramate make Nexplanon ineffective?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I take 44 mg of Topiramate twice daily and also take Nexplanon. Does this medication increase the risk of pregnancy if my partner ejaculates inside me and makes Nexplanon ineffective?

Answered by Dr. Obinna Ugwuoke

Education:

Fellowship in Obstetrics and Gynecology

Professional Bio:

Dr. Obinna Ugwuoke is a dedicated Medical Professional who achieved a Fellowship in Obstetrics and Gynecology from the West African College of Surgeons in 2022. With three years of clinical experience. He contributes his expertise to NAF Hospital in Lagos, Nigeria. Driven by passion and skill, he continues to make significant strides in women's healthcare.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I have read the query and understand your concern.

Topiramate (anticonvulsant) causes a decrease in the serum etonogestrel (the active component in Nexplanon) level required to inhibit ovulation. However, this is dosage dependent. Topiramate of a daily cumulative dosage of 100 mg (milligrams) or less does not have a significant effect on the serum level of etonogestrel. So, since your daily cumulative dosage is 88 mg, it will not make your Nexplanon ineffective and it will not increase your risk of getting pregnant. However, if you want to increase your dosage of Topiramate above 100 mg per day, do let me know or your gynecologist, so that you can be reassessed and appropriate measures can be taken to prevent you from getting pregnant.

I hope it helps.

Take care.

The Probable causes

At lower dosage of Topiramate (less than 100 mg (milligrams) per day), your Nexplanon will still be effective at preventing pregnancy.
Medically reviewed by Dr. K. Shobana
Published At February 18, 2025
Reviewed At February 18, 2025

Education:

Fellowship in Obstetrics and Gynecology

Professional Bio:

Dr. Obinna Ugwuoke is a dedicated Medical Professional who achieved a Fellowship in Obstetrics and Gynecology from the West African College of Surgeons in 2022. With three years of clinical experience. He contributes his expertise to NAF Hospital in Lagos, Nigeria. Driven by passion and skill, he continues to make significant strides in women's healthcare.

This doctor is not available for online consultations on the platform anymore.

Education:

BDS

Professional Bio:

Dr. K. Shobana is a Dental Surgeon specializing in oral health and dental care. She is skilled in preventive dentistry and provides oral hygiene education. She can do restorative treatments such as fillings and crowns. She can handle periodontal problems such as gum diseases and periodontitis. She can do root canal treatment.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

Fellowship in Obstetrics and Gynecology

Professional Bio:

Dr. Obinna Ugwuoke is a dedicated Medical Professional who achieved a Fellowship in Obstetrics and Gynecology from the West African College of Surgeons in 2022. With three years of clinical experience. He contributes his expertise to NAF Hospital in Lagos, Nigeria. Driven by passion and skill, he continues to make significant strides in women's healthcare.

This doctor is not available for online consultations on the platform anymore.

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