Common "Transferrin Saturation" queries answered by top doctors | iCliniq

Transferrin Saturation

The transferrin saturation is the portion of iron that is found in the blood. Transferrin is the protein that has the capacity to bind to iron, which gets travelled around the body and to the bone marrow to produce hemoglobin. Measuring transferrin indicates the level of iron saturation in the blood. The typical value for transferrin is 204–360 milligrams (mg) per deciliter. An amount greater than this determines a low level of iron saturation.

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I have muscle pain, tiredness, shortness of breath, mild vertigo, gastritis, and constipation. Why?

Query: Hello doctor,My recent blood tests show high homocysteine and low ferritin, vitamin B12, folate, methylmalonic acid, iron, TIBC, and transferrin saturation are normal. My symptoms are muscle pain, tiredness, shortness of breath, and mild vertigo. I have a history of gastritis and constipation. Can y...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to icliniq.com. I read your query and can understand your concern. Low ferritin is suggestive of a decrease in iron storage. So for that, hemoglobin value also should be known. If hemoglobin is also low, then your symptoms can be due to iron deficiency anemia. I suggest taking iro...  Read Full »

I am pregnant with hereditary spherocytosis and abnormal blood test results. What should I do?

Query: Hello doctor, I am eight weeks pregnant. This is my first pregnancy, and I have nausea and constipation. Early pregnancy blood work showed an increased transferrin saturation, mild anemia, and higher B12 level in blood. I was diagnosed with hereditary spherocytosis a few years ago, so my spleen is m...  Read Full »


Dr. Mubashir Razzaq Khan

Answer: Hello, Welcome to icliniq.com. Thank you for your query. I read your query and understand your concern. You need to keep your vitamin B12, folic acid, pyridoxine, vitamin D, and iron within the upper limits of reference ranges. As hereditary spherocytosis is a high-utility state of the body due ...  Read Full »

Is it normal to have a iron saturation index of 49 percent in woman?

Query: Hi doctor, I am 57 years old. I have an iron level of 130 mcg/dL and an iron-binding capacity of 265 mcg/dL. My iron saturation index was 49 percent. Is it low for a normal woman?   Read Full »


Dr. Anshul Varshney

Answer: Hi, Welcome to icliniq.com. Kindly attach your complete blood count report. So that I can help you better.  Read Full »

My transferrin saturation value is high. What could be the reason?

Query: Hello doctor, I am a 30-year-old female. I had a recent blood test and my iron studies from past four years till now has been attached. My main concern is my T Saturation. I have been genetically tested for hemochromatosis, which came back negative. I am also on zero supplements, multivitamins, etc...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to the icliniq.com. I have read your question and report (attachment removed to protect patient identity). Your transferrin saturation is slightly high. It is usually high in case of hemochromatosis in which iron overload occurs. But serum ferritin is within range and not elevated. ...  Read Full »

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