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Can high cholesterol, low WBC, and high TSH cause weakness?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

It has been one month since I started feeling weak. My recent blood tests show a low WBC count of 3,100 cells per microliter, platelet count of 15,000 cells per microliter with a few giant platelets, borderline blood sugar levels, total cholesterol 240 mg/dL, LDL 145 mg/dL, and TSH of 7.0 µIU/mL with normal T3 and T4. Tumor markers show AFP 6.1 ng/mL and CEA within the normal range. What does this signify?

Please guide.

Thank you.

Answered by Dr. Mona Kamal

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

I read your query and understand your concerns.

Adults should keep their total cholesterol levels below 200 mg/dL (yours is 240 mg/dL, which is high). HDL (high-density lipoprotein) cholesterol, the good cholesterol, should be at least 50 mg/dL in adult females. LDL (low-density lipoprotein) cholesterol at 145 mg/dL falls into the borderline-high range. These results indicate high blood cholesterol and a disturbed lipid profile that should be corrected.

Your WBC (white blood cell) count is 3,100/µL, indicating leukopenia, which may reduce the body’s ability to fight infections. Platelet count is 15,000/µL, indicating severe thrombocytopenia. TSH (thyroid-stimulating hormone) is 7.0 µIU/mL with normal T3 (triiodothyronine) and T4 (thyroxine) levels, suggesting subclinical hypothyroidism. AFP (alpha-fetoprotein) is 6.1 ng/mL (within normal range), and CEA (carcinoembryonic antigen) is also within normal limits.

As a conclusion of your blood test, you have to control your cholesterol and lipids, correct leukopenia, and the subclinical hypothyroidism.

I hope this answers your query. Feel free to reach out anytime.

Thank you.

Answered by Dr. Mona Kamal
Medically reviewed by iCliniq medical review team
Published At October 20, 2025
Reviewed At October 20, 2025

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

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