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What could be the reason for the low WBC count in an otherwise healthy female?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am a 40-year-old female with no symptoms and in good physical condition. I typically have a blood test every year. I discovered that I had mild leukopenia at 3900/mm since the start of the year, but recently, my blood test has come back at 3600/mm.

My differential counts are within the normal range. My hemoglobin is 12.7 g/dL, and I have mild Sjogren's syndrome, for which my doctor has said that no treatment is necessary.

Due to inadequate ovarian reserve, I have no children, and my globulin is significantly higher (4.6 g/dl) on the LFT report. Due to subclinical hypothyroidism, I have been taking Thyronorm 50 mcg since last year.

  1. So my inquiry is, what comes next?
  2. My WBC is low; why?
  3. Do I need to rule out anything with bone marrow aspirations?

Please help.

Thank you.

Answered by Dr. Goswami Parth Rajendragiri

Education:

MBBS

Professional Bio:

Dr. Goswami Parth Rajendragiri is an experienced General Physician and Pathologist with extensive years of clinical expertise. He specializes in diagnosing and managing a wide range of medical conditions while providing holistic care to patients. As a Pathologist, he is skilled in performing and interpreting laboratory investigations that aid in accurate diagnosis and treatment planning. Dr. Rajendragiri is dedicated to delivering patient-focused care with a strong emphasis on preventive medicine and overall well-being.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

You are having Sjogren's syndrome as per the mentioned history.

Your leukocyte count is mildly low, which might be due to Sjogren's syndrome. Your peripheral smear examination report is normal, and your hemoglobin level and platelet count are also within limits.

So, in my opinion, there is no need for a bone marrow aspiration study. So no need for further workup.

If dry mouth, joint pain, muscle pain, and dry eye symptoms are troublesome, then you can consult a rheumatologist for a detailed evaluation and management.

I hope I have answered your question.

Let me know if I can assist you further.

Regards.

Medically reviewed by iCliniq medical review team
Published At February 10, 2023
Reviewed At April 24, 2026

Education:

MBBS

Professional Bio:

Dr. Goswami Parth Rajendragiri is an experienced General Physician and Pathologist with extensive years of clinical expertise. He specializes in diagnosing and managing a wide range of medical conditions while providing holistic care to patients. As a Pathologist, he is skilled in performing and interpreting laboratory investigations that aid in accurate diagnosis and treatment planning. Dr. Rajendragiri is dedicated to delivering patient-focused care with a strong emphasis on preventive medicine and overall well-being.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Goswami Parth Rajendragiri is an experienced General Physician and Pathologist with extensive years of clinical expertise. He specializes in diagnosing and managing a wide range of medical conditions while providing holistic care to patients. As a Pathologist, he is skilled in performing and interpreting laboratory investigations that aid in accurate diagnosis and treatment planning. Dr. Rajendragiri is dedicated to delivering patient-focused care with a strong emphasis on preventive medicine and overall well-being.

This doctor is not available for online consultations on the platform anymore.

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