Sjogren's Syndrome

Sjogren’s syndrome or sicca syndrome is a triad of keratoconjunctivitis sicca, xerostomia, and rheumatoid arthritis. Dry eyes and mouth characterize this syndrome. Henrik Sjogren described it in 1933. It is an autoimmune disorder. It affects the mucous membranes of the eyes and mouth that lead to their decreased secretion. It also leads to generalized dryness.

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I am suffering from an eye infection and rheumatoid arthritis. Is it curable?

Query: Hello doctor, I am suffering from an eye infection (rheumatoid arthritis). My HLA b27 report is positive. What medicines should I take, Is it curable? If it is permanent what preventions I can take? Please help.  Read Full »

Dr. Bandivadekar Pooja Mohan

Answer: Hello,Welcome to arthritis has a dry eye as an association which leads to frequent infections (Sjogren syndrome). There are two lines of treatment1. Controlling ocular dryness and inflammation.2. Controlling systemic inflammation.For ocular dryness, a combination of tear subst...  Read Full »

Should I do a bone marrow aspiration to find out why my WBC count is low?

Query: Hi doctor, I am 40-year-old female with no symptoms, and in good physical condition. I typically have a blood test every year. I discovered that I had mild leucopenia at 3900/mm since the start of the year, but recently, my blood test has come back at 3600/mm. My differential counts are within the n...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to the, You are having Sjogren's syndrome as per mentioned history. Your leukocyte count is mildly low, which might be due to Sjogren's syndrome. Your peripheral smear examination report is normal and hemoglobin level and platelet count are also within limit. So accor...  Read Full »

Does blood in sputum in the mornings, dry throat and mouth mean cancer?

Query: Hello doctor, For about a year I have been coughing up mucus with a small fleck or flecks of blood in it. It happens only in the morning and not every day. I have noticed that my throat and mouth are very dry on the days that it happens. I also have little flecks of blood in my snot when I blow my ...  Read Full »

Dr. Mit Dharsandiya

Answer: Hello, Welcome to I went through your case carefully. I need some more information so that I can help you. Do you feel dryness in the eyes also? Some foreign body sensation in eyes? Do you need to drink some liquid with food to swallow it?  Read Full »

I have been having ear problems for the past three years. Please look at the MRI of my parotid glands to find any abnormality.

Query: Hi doctor, I have been having problems with my left ear for a few years. Around the same time, I became ill with POTS-type symptoms, but I am not sure if they are related to this query. I am experiencing pain, pressure, tinnitus, dizziness, and vertigo. I also have a globus sensation. I also have a ...  Read Full »

Dr. Akshay B K

Answer: Hello, Welcome to Please do not worry; I understand your concern and will try and help you out. Please get back to me with the answers to the following questions so that we can arrive at a diagnosis. 1. The pain which is in the left ear, is it always present? Is there any ear discha...  Read Full »

I have autoantibodies in my blood and some related specific proteins. What could they indicate?

Query: Hello doctor, I have autoantibodies in my blood and some related specific proteins. I still do not have serious symptoms. I can send my results.  Read Full »

Dr. Ashaq Hussain Parrey

Answer: Hello, Welcome to I went through your post and investigations. There are a few significant results in the autoimmune profile. Your ANA (antinuclear antibody), dsDNA (double-stranded deoxyribonucleic acid), and anti-Ro are positive, which is suggestive of SLE (systemic lupus erythemato...  Read Full »

Do my eyes, throat, mouth, and nose become dry at night due to Sjogren's syndrome?

Query: Hello doctor, I am a 45-year-old male. I had a physical examination done ten months ago. My reports came normal. I began having dry eyes, dry throat, and mouth. My antibody test results came negative. My doctor said the ANA is a false positive, although I have lingering dryness of the throat, mouth,...  Read Full »

Dr. Ashaq Hussain Parrey

Answer: Hello, Welcome to You have dry eyes and mouth symptoms with positive ANA (antinuclear antibody) test. ANA is positive in 5 % of the general population and carries little significance unless associated with clinical symptoms. However, Sicca syndrome's symptoms need to be evaluated by sia...  Read Full »

Is Sjogren's syndrome the only cause for having dry eyes and dry mouth?

Query: Hi doctor, I am a 20-year-old male without a history of autoimmune disease in my family. But I have dry eyes and dry mouth for four months and I am unable to find the cause. I do not have dry eyes and mouth every day and it does not occur together. Recently, I also have joint pain while walking. ...  Read Full »

Dr. Reinhard Spyra

Answer: Hi, Welcome to The provided information is not sufficient to establish a definite diagnosis. Kindly give some additional information regarding dry eyes and dry mouth. Please mention whether you experienced dry mouth daily for more than three months. Please mention whether you had any ...  Read Full »

Can I suffer from hepatitis C even if my hepatitis test reports are negative?

Query: Hello doctor, I recently had a complete lab test with my primary care provider in which my alanine transaminase (ALT) was 60 units per liter. My gamma globulin returned at 3.3 g/dL, and Sjogren's anti-SSA and anti-SSB levels were more than eight units per mL. The rheumatoid factor level was 34.2 IU ...  Read Full »

Dr. Mohamad Ali Rida

Answer: Hello, Welcome to I doubt you have hepatitis C because the test is negative. It is common to have Sjogren's syndrome with positive anti-SSA (Sjogren's syndrome A), anti-SSB (Sjogren's syndrome B), and rheumatoid factor (RF). It all depends on your symptoms. Do you experience dryness in ...  Read Full »

Can I have lymphoma, kidney diseases, and eye problems due to secondary Sjogren's syndrome?

Query: Hello doctor, I have had dermatomyositis for three years and was asked to take tablet Cellcept. Before being diagnosed with dermatomyositis, I developed dry eye disease due to meibomian gland dysfunction. After taking the medicines, I had dryness in my mouth. I tested negative for anti-SSA Ro and an...  Read Full »

Dr. Mohamad Ali Rida

Answer: Hello, Welcome to Do not worry, as you are receiving the best treatment for dermatomyositis. Secondary Sjogren's syndrome is a very common autoimmune disease. Being on tablet Cellcept (Mycophenolate mofetil 500 mg) is more than enough to prevent complications of Sjogren's syndrome. Yo...  Read Full »

My wife has Sjogren's syndrome and has been taking tablets Sulfasalazine. I am worried if it will impair her Type 1 interferon production. Please help.

Query: Hi doctor, My wife has had Sjogren's syndrome and related rheumatoid arthritis for about ten years. She has been experiencing a flare for five months now, which has migrated from her knees to her heel and hands. She is nearing 70. She is currently on tablet Sulfasalazine 500 mg, two in the morning a...  Read Full »

Dr. Sugreev Singh

Answer: Hi,Welcome to can understand your concern.It differs from person to person. Some people have a higher risk, while some do not. But since she has Sjogren's, I would suggest you continue with the same medicine and take precautions for COVID. Even if she stops the medication, there are ch...  Read Full »

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