Is hormone–phenotype conflict linked to Chapelle syndrome?

Hi doctor,

I have been experiencing extreme tension, pressure, and pain due to conflict between my endocrine physiology and male phenotype, female-structured hands, high progesterone levels in my blood alongside high cortisol, suspecting a rare form of Chapelle syndrome despite having functional male genitalia due to cryptorchidism in childhood and past testicular atrophy.

In response to being denied female HRT (Hormone Replacement Therapy), I am writing out of desperation. This denial stems from an alleged non-compliance with a psychiatric diagnosis of gender incongruence, even though I am completely functional and gainfully employed. My case is supported by an electronic certificate from the public Health, which attests to the absence of any physical or psychological damage. Furthermore, I possess a psychiatric certificate from a head physician confirming that I do not suffer from any mental disorder and that my condition has not been clinically proven to be one. Additionally, I have an MRI brain scan, analyzed by an expert, which proves that all of my brain structures are functioning properly.

But my late mother came from a family of chronic daily alcoholics, and her mother had alcohol induced schizophrenia, and my mother ignored the warnings of doctors that told her not to get pregnant due to her brain angioma that was localized in a sensitive area of the brain, because they were aware that her condition could disrupt my development. She did not listen, did not remove the tumor with a gamma knife, and she smoked and drank heavily during early pregnancy, and malnutrition was present as well.

I am furious for rejecting my karyotype test request, even though my symptoms point to a rare syndrome, due to male phenotype and testosterone, I had debilitating migraines that sometimes lasted 36 hours (one attack only), developed a serious skin autoimmune disorder that manifests with high IgE and elevated marker for SCC.

I have nurse qualifications, and I am fed up with doctors' rigid rules. Since my chromosomes have not been analyzed, nobody has the right to claim that I am biologically male; my prolactin is high as well. But I work for a low salary, which prevents me from radically feminizing the body. The torture of my organism is immense. And even if I accepted a gender incongruence diagnosis that cannot be applied in my case, I would get microdoses of hormones after a five-year humiliating process that would not make a real change and feminize my body. I could not prevent the disruption of the p53 gene during my fetal development. What should I do?

Thanks.

Hi doctor,

Thanks for the reply.

Even my last doctor, who has more than 40 years of clinical experience, told me that I am a woman by hormones, everything despite my male phenotype, but unfortunately, the national health committee ignored my legal request for transition due to my non-compliance with F64.

I have been discriminated against horrifically, endured outrageous abuse from psychiatrists, simply for demanding a karyotype test at the genetic institute upon recommendation from my doctor.

Instead of behaving professionally, they locked me up for five days, dosing me with Risperidone, Quetiapine, and Olanzapine, and gave me a F28 diagnosis. Luckily, an associate of my psychiatrist intervened, telling them that I am not a threat to myself and others, so I was released on the seventh day.

I reported the case to the administration court via e-mail, though, because it is outrageous that in such Western countries, such things can happen, and a French lawyer told me that the confinement was likely illegal, given that they released me within seven days, which means that they did not have consent from the local district judge.

Unfortunately, even the country demands F64 for HRT, so I am stuck as pain intensifies. I am not being difficult or stubborn, but I can never accept such a diagnosis because discrimination would become unbearable, and I would lose my job. Please understand where I am coming from. Even in other countries, individuals like me are waiting for 10 years for HRT after accepting a psychiatric diagnosis, but they do not get the therapy; it is a trap for naive people.

My mother died four months after giving birth to me via C section from a brain hemorrhage so you can understand why my condition cannot possibly be mental disorder, her HPA axis must have been disrupted as she was in constant stress due to war that was ongoing back then (1993), she died at age 33, after spending three weeks in a coma in 1994.

Thanks.