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Effects of Steroid Medication on Immunity

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Steroids can affect the immune system in various ways, depending on the nature and the length of steroid usage. Read the below article to know more.

Written by

Dr. Durga. A. V

Medically reviewed by

Dr. Kaushal Bhavsar

Published At October 31, 2023
Reviewed AtOctober 31, 2023

Introduction:

Steroid drugs such as Prednisone can impact the immune system. By calming the immune system, these drugs can reduce inflammation. This is beneficial for autoimmune diseases like lupus (when the body's immune system attacks its tissues and organs) and rheumatoid arthritis, in which the immune system unintentionally targets healthy tissue. The low immune system, nevertheless, can also increase an individual's susceptibility to illnesses. Inform the doctor as soon as one notices an infection, if one take a steroid prescription so that the illness may be treated immediately. It is also critical to remember that steroid medicine use over an extended period may have greater negative impacts on the immune system.

What Are Steroids?

Steroids are a class of drugs that include synthetic testosterone. They are often ingested as tablets, injections, or topical creams. Numerous medical problems, including inflammation (a component of the body's defensive system), asthma (a disorder when the airways are constricted, swollen, and perhaps producing additional mucus), and some forms of cancer, are frequently treated with steroids. They can also be utilized to build muscle and enhance sports performance. However, using steroids without a doctor's approval is often not advised due to the possibility of major adverse effects.

What Are the Effects of Steroid Medication on Immunity?

The immune system can be impacted by a variety of steroids, often known as corticosteroids. These drugs may suppress the immune system, frequently used to relieve inflammation, making people more prone to infections. Steroids can sometimes treat immune system conditions such as rheumatoid arthritis, lupus, and asthma, but they can also damage the immune system. In several cases, the immune system may be impacted by steroid medicine, including

  • It may cause immune system suppression. The immune system's capacity to create the molecules that lead to inflammation can be decreased by steroids.

  • This may make it more difficult for the body to fight against infections and make getting an infection while taking steroids more likely.

  • Steroids can raise the likelihood of contracting infections like sepsis (the body's severe reaction to an illness) and pneumonia (an illness that causes one or both lungs' air sacs to swell) because they depress the immune system.

  • While using steroids, it is critical to lower the risk of infection, including often washing hands and avoiding close contact with ill individuals.

  • Steroids can also obstruct the body's capacity to repair tissues, which can cause delayed wound healing.

  • Steroid usage over a long period can also cause a reduction in bone density, which can raise the risk of fractures and osteoporosis (creating brittle and fragile bones).

What Are the Advantages of Steroid Medication on the Immunity System?

These steroid drugs act by lowering inflammation and dampening the immune system, and they can treat various illnesses. The following are a few possible benefits of utilizing steroid medications:

  1. Reduces Inflammation: In the body, inflammation can cause symptoms of diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. Steroids can be useful in lowering this inflammation.

  2. Suppresses the Immune System: The immune system may malfunction and attack healthy cells and tissues in specific situations. In the circumstances like autoimmune disorders, when the immune system is attacking healthy cells, steroids can assist in inhibiting the immune system, which can be advantageous.

  3. Treats Allergies: The itching, swelling, and breathing difficulties associated with allergies can be effectively treated with steroids.

  4. Treats Cancer: Several cancers, including leukemia (bone marrow and lymphatic system cancer are examples of cancers that affect the body's blood-forming tissues), can be treated with steroids and other drugs.

  5. Prevention of Autoimmune Reactions: The immune system occasionally misfires and attacks the body's healthy cells. To treat autoimmune illnesses, steroids can inhibit the immune system and stop it from attacking healthy cells.

  6. Prevention of Organ Rejection: The new organ may be attacked by the immune system after an organ transplant if it recognizes it as abnormal. Steroids can improve overall immune system suppression and lower the risk of organ rejection.

What Are the Disadvantages of Steroid Medication on the Immunity System?

Using steroids can be quite successful in treating some medical issues, but they can also have detrimental effects on the immune system. As such, it is vital to remember that one shouldn't stop taking them without first talking to the doctor.

The immune system may be harmed by the use of steroid drugs in numerous ways:

  • Steroid users are more likely to get infections since steroids depress the immune system. People with a high risk of infection, such as HIV (human immunodeficiency virus) or AIDS (acquired immunodeficiency syndrome), or those who have had organ transplants, should be especially aware of this.

  • Steroids can also delay wound healing and make it more difficult for wounds to heal completely.

  • Additionally, steroids may lessen the efficiency of immunizations, which makes it more difficult for the body to develop immunity to specific illnesses.

  • Some vitamins and minerals may not be properly absorbed when steroids are used long-term, and nutritional shortages may result.

  • Steroids can have negative side effects and affect the immune system, including mood swings, acne, and weight gain.

  • Steroid users can experience high blood pressure, which raises their risk of heart attacks and strokes.

  • Steroid users may have skin thinning, easy bruising, and the appearance of stretch marks.

  • Steroid usage for an extended period can also raise the chance of developing cataracts (a blurred lens), a disorder that results in clouding the eye's lens.

Conclusion:

Long-term steroid usage might weaken the immune system, increasing the risk of infection. A healthcare professional should only use steroid drugs as prescribed because misuse might have negative effects. Discussing these concerns with the healthcare practitioner if one is using steroid drugs and is worried about how they may affect the immune system is important. They can advise the most appropriate course of action for the specific situation. It may be suggested to those using steroids to take precautions against contracting illnesses, such as washing their hands and avoiding close contact with sick people. People who use steroid drugs must be aware of these possible side effects and adhere to their doctor's recommendations to reduce risks.

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Dr. Kaushal Bhavsar
Dr. Kaushal Bhavsar

Pulmonology (Asthma Doctors)

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