Immune Disorders

Rheumatoid Arthritis

Written by
Dr. Sneha Kannan
and medically reviewed by Dr. K Shanmuganandan

Published on Jul 03, 2019 and last reviewed on Oct 10, 2019   -  4 min read

Abstract

Abstract

Rheumatoid arthritis (RA) is an autoimmune disorder that causes chronic inflammation and pain in the joints throughout the body

Rheumatoid Arthritis

What Is Rheumatoid Arthritis?

Rheumatoid arthritis (RA) is an autoimmune disorder that causes chronic inflammation and pain in the joints throughout the body. It is a long-term and disabling disease.

This disease usually affects the joints of the hands and feet first, and if one side of the joint is affected, it is most likely to affect the joint on the other side also.

What Are the Types of Rheumatoid Arthritis?

The common types of RA are:

  1. Seropositive rheumatoid arthritis - 60 to 80 % of patients test positive for antibodies called anti-cyclic citrullinated peptides (anti-CCPs) or rheumatoid factor (RF).

  2. Seronegative rheumatoid arthritis - Patients test negative for anti-CCPs and rheumatoid factor but still show symptoms of RA.

What Is an Autoimmune Disorder?

The immune system prevents diseases by attacking the virus or bacteria or any foreign objects that enter the body. When this immune system starts identifying the cells of the body as foreign objects, they start attacking them, which leads to autoimmune disorders or diseases.

What Are the Signs and Symptoms of Rheumatoid Arthritis?

The signs of rheumatoid arthritis are:

  • Pain, tenderness, stiffness, swelling, redness, and warmth on involved joints usually in a symmetrical manner.

  • Walking with a limp.

  • Loss of joint function

Small joints like the joints in the fingers and toes are affected first usually. In the later stages, it spreads to the wrist, knee, ankle, hips, shoulders, and elbows.

The symptoms aggravate during periods known as flares, and during the remission period, the symptoms disappear. The symptoms can be mild to severe for different patients.

How Do You Get Rheumatoid Arthritis?

When the immune system attacks the membrane lining the joints (synovium), it leads to inflammation and thickening of the synovium. This inflammation eventually affects the cartilage and bone in the joint. The tissues that hold the bones in the joint together (ligaments and tendons) stretch and weaken, making the joint lose their shape and alignment.

Pathophysiology:

The three phases in which RA progresses are:

Initiation phase.

Amplification phase.

Chronic inflammatory phase.

What Is the Difference Between Osteoarthritis and Rheumatoid Arthritis?

What Are the Risk Factors for Rheumatoid Arthritis?

Factors that increase the risk of an individual acquiring RA are:

  • Women are more prone than men.

  • Middle-aged people.

  • Family history.

  • Smoking.

What Are the Complications and Conditions Associated with RA?

It has been noted that people with RA commonly develop the following conditions:

  • Osteoporosis.

  • Rheumatoid nodules (firm lumps under the skin).

  • Sjogren’s syndrome.

  • Frequent infections.

  • Atherosclerosis.

  • Lymphoma.

  • Carpal tunnel syndrome.

  • Cervical myelopathy.

  • Depression and anxiety.

How Is Rheumatoid Arthritis Diagnosed?

Diagnosis of RA needs a lot of blood test and imaging. If you have symptoms of RA, consult a rheumatologist. The doctor will ask you about the symptoms you are having and will conduct a few physical examinations. The doctor will look for redness, tenderness, and warm in the affected joint. To rule out all other causes and to check the damages done to your bones, he or she might order some blood and other tests.

You might have to get the following tests done:

  • Blood test - A blood test is done to look for the presence of rheumatoid factor and anti-CCP antibodies. C-reactive protein and erythrocyte sedimentation rate (ESR) are also elevated in RA patients.

  • Imaging tests - X-rays, MRI, and ultrasound are done to see the progression of the disease.

How to Treat Rheumatoid Arthritis?

Starting medicines early keep the disease in remission period. The treatment options include:

Medicines:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) - Ibuprofen and Naproxen sodium to reduce pain.

  • Corticosteroids - Prednisone helps reduce inflammation and slows the progression of joint damage.

  • Disease-modifying antirheumatic drugs (DMARDs) - Methotrexate, Leflunomide, and Sulfasalazine reduces the progression of this disease.

  • Biologic response modifiers - Abatacept, Adalimumab, Infliximab, Rituximab, Etanercept, etc., are a new class of DMARDs.

Occupational Therapy:

An occupational therapist will teach exercises to make your joint more flexible and easier ways to do day-to-day activities.

Surgery:

In case your symptoms are not getting better with medicines and therapies, your doctor might suggest you undergo the following surgeries to repair damaged joints:

  • Synovectomy - The inflamed synovium is removed.

  • Tendon repair - The inflamed and loosened or ruptured tendons are repaired.

  • Joint replacement - Damaged joints are replaced by prostheses.

  • Joint fusion - When replacement cannot be done, the joints are fused together to reduce pain.

Lifestyle Changes:

  • Perform regular gentle exercises like walking, swimming, water aerobics, etc.

  • Apply heat and cold compressions.

  • Manage stress through yoga and meditation.

What Foods to Avoid and Eat If You Have Rheumatoid Arthritis?

Diet might not help treat RA, but some food items might cause flares and others might help reduce inflammation.

Foods to avoid:

  • Red meat.

  • Dairy.

  • Corn oil.

  • Fried and processed food.

  • Too much salt and sugar.

  • Alcohol.

Food to eat:

  • Broccoli.

  • Fatty fish.

  • Cherries.

  • Beans.

  • Citrus fruits.

  • Ginger.

  • Nuts.

  • Whole grains.

  • Olive oil.

If your symptoms are suggesting arthritis or are getting worse, consult an experienced rheumatologist online. You can ask queries or do phone or video consultation, which will help find the best treatment option for you.

Frequently Asked Questions


1.

How long can someone live with rheumatoid arthritis?

If identified early and palliative care is started, rheumatoid arthritis patients can expect a normal life span. But patients who develop complications like atherosclerosis, cirrhosis, etc., the life expectancy shortens roughly by 10 to 15 years.

2.

How serious is rheumatoid arthritis?

It is a chronic and debilitating disease. RA causes inflammation of the joints and other symptoms, which can be managed with the help of medicines and therapies. But, RA patients develop several severe complications, which can also be fatal.

3.

What are the 4 stages of rheumatoid arthritis?

The 4 stages of progression of RA are:
- Stage 1 - The immune system attacks the joint tissue.
- Stage 2 - The body starts producing antibodies, which results in inflammation of joints.
- Stage 3 - This inflammation makes the joints to bend and fingers to get crooked.
- Stage 4 - If left untreated, the joint is destroyed and bones in the joint get fused.

4.

What age does arthritis usually start?

The first signs of RA usually begin at around 20 to 30 years of age.

5.

What happens if you leave rheumatoid arthritis untreated?

If RA is not detected and treated early, it can lead to a lot of complications like:
- The cartilage and bone in the joint are damaged or destroyed, which can lead to joint deformities.
- Loss of joint function and disability.
- Osteoporosis.
- Coronary artery disease.
- Anemia.
- Depression.

6.

How do you feel during a rheumatoid arthritis flare-up?

The period when there is increased disease activity, which causes severe joint pain and stiffness, is called a flare-up. RA patients suffer from flare-ups on and off throughout their lives.

7.

What is end-stage rheumatoid arthritis?

The final stage or end-stage of rheumatoid arthritis is when the inflammation process destroys the bones and cartilages in the bone. It results in permanent deformation and loss of joint function.

8.

Is rheumatoid arthritis worse at night?

Join pain and stiffness can increase at night. This is because joint pain interferes with sleep, which makes you stressed and depressed, which in turn makes the pain worse.

9.

What causes rheumatoid arthritis to flare up?

RA flare-up can result from a number of triggers like:
- Overexertion.
- Emotional stress.
- Food allergens.
- Environmental factors.

10.

Can Rheumatoid Arthritis Be Cured?

As of now, there is no medicine that can cure rheumatoid arthritis. The drugs that are used to manage this condition help ease symptoms, stop joint damage, and keep it in remission.

11.

Is rheumatoid arthritis caused by stress?

RA is not caused by stress, but too much stress is linked to worsening of symptoms.

12.

What is the most painful type of arthritis?

There are various types of arthritis like osteoarthritis, rheumatoid arthritis, gout, psoriatic arthritis, etc., and all of them cause different types of pain. Depending on the cause and severity, all types of arthritis are painful.

13.

What is the best vitamin for arthritis?

Vitamins and supplements that help manage joint pain and inflammation are glucosamine, omega-3 fatty acids, and vitamin D.

14.

What is the best exercise for rheumatoid arthritis?

Exercises that can relieve joint pain and stiffness are:
- Stretching.
- Walking.
- Tai chi and Yoga.
- Pilates.
- Swimming and water aerobics.
- Cycling.
- Strength training.

15.

How long does it take for rheumatoid arthritis to progress?

Depending on the severity and triggers, RA progression can take months or years.

16.

Is walking good for arthritis?

Yes, walking helps relieve pain and stiffness. It is a low-impact form of exercise, which helps maintain the heart and joint health.

Last reviewed at:
10 Oct 2019  -  4 min read

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