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Is Yaz safe for acne if I do not have a gallbladder?

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Patient's Query

Hello doctor,

I am a 25-year-old female. I have had acne for five months.

Can I take Yaz pills, even if I do not have a gallbladder?

Please help.

Thank you.

Hello,

Welcome to icliniq.com.

I have read your query, and I understand your concern when it comes to hormonal pills, especially for acne. It is very normal to worry about safety. Let me explain this clearly and reassure you.

Yes, you can take Yaz pills (Drospirenone and Ethinyl estradiol) for acne even if you do not have a gallbladder. Having your gallbladder removed (cholecystectomy) is not a contraindication to using Yaz. Yaz contains Ethinylestradiol and Drospirenone, and these hormones are metabolized mainly by the liver, not the gallbladder. So, the absence of the gallbladder alone does not make Yaz unsafe.

However, Yaz should be used only if there are no other contraindications. You should not take Yaz if you have a history of blood clots, migraine with aura, uncontrolled high blood pressure, smoking (especially if over 35), known liver disease, or hormone-dependent cancers. If none of these are present, Yaz is prescribed for hormonal acne, especially acne that persists for months, flares around periods, or involves the chin and jawline.

For acne, improvement with Yaz usually starts after two to three months, and full benefit may take four to six months, so patience is important. During this time, it is better to combine it with appropriate topical acne treatment like Benzoyl peroxide gel, Benzac gel (Benzoyl peroxide gel), and apply a pea-sized amount at night on the face for better results. Mild nausea or breast tenderness can occur initially but usually settles within a few weeks.

I hope this answers your query.

Please let me know if I can assist you further.

Thank you.

Answered byDr. Misha Saghir

Medically reviewed byiCliniq medical review team

Published At March 26, 2026
Reviewed AtMarch 27, 2026

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