HomeAnswersDermatologyamelanotic lesionIs amelanotic melanoma a lesion to be concerned?

How does amelanotic melanoma look like?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Vinodhini J.

Published At January 21, 2020
Reviewed AtJune 25, 2023

Patient's Query

Hello doctor,

Does this lesion in my lower back (pink) appear to be worrisome for amelanotic melanoma? It now appears flesh-colored. Pictures attached.

Hi,

Welcome to icliniq.com.

I have seen the pictures. (attachment removed to protect patient identity).

Yes, they are looking like melanoma. Signs of vascularization in the previous nevus is suggestive of melanoma. Kindly consult a local dermatologist as dermoscopic and histological examinations are required to confirm the diagnosis.

Patient's Query

Thank you doctor,

As far as I know, it is not a previous nevus, though. Unless you can tell somehow that it was? I thought arborizing or branched serpentine vessels were much more commonly found in basal cell carcinomas, and amelanotic melanoma was more commonly polymorphous vessels.

Hello,

Welcome back to icliniq.com.

Actually amelanotic melanoma can also occur from an intradermal nevus, so it is not necessary to present over the skin. The use of dermoscopy in clinical practice will improve the identification of skin lesions although, unfortunately, it will not guarantee a diagnostic accuracy of 100%. At times this BCC (basal cell carcinoma) pattern will be difficult to differentiate from amelanotic. Melanoma and the final diagnosis should rest on the histopathologic evaluation of the lesion.

Other differentials include microvenular hemangioma, angioma serpiginosum, blue rubber bleb nevus syndrome. Dermoscopic finding of Spitz nevi is also the same as you had sent to me. So I would highly recommend you to go for histopathological examination.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Atishay Bukharia
Dr. Atishay Bukharia

Dermatology

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