Common "Histopathological Examination" queries answered by top doctors | iCliniq

Histopathological Examination

Histopathological examination is viewing tissues and other cells obtained through biopsy under a microscope. Histological sections are made of the biopsy specimen, which are then mounted on a glass slab to view under the microscope. It is used to diagnose the type of cancer cells present and the manifestation of the disease.

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Why do I have multiple skin lumps on the elbow?

Query: Hi doctor, I have had these multiple skin lumps on the very tip of my elbow for a couple of years now. I have attached the photos for your reference. They look like a wart but are clustered together. Every medication I have used on them has done absolutely nothing. Recently, they have begun to grow ...  Read Full »


Dr. Atishay Bukharia

Answer: Hi, Welcome to icliniq.com. These might be the lesion of sarcoidosis, lupus vulgaris or nodular xanthoma (attachment removed to protect patient identity). The only histopathological examination could confirm the diagnosis, so I would suggest you go for the one. A punch biopsy is the most preferred...  Read Full »

My laboratory report suggests superficial basal cell carcinoma. Please explain the disease.

Query: Hello doctor, I am 67 years old male and weigh 110 pounds. Below is a report about a small piece of skin that was examined. The following observation was found: The skin sample was taken from the left side of the chest. When looked at with the naked eye (gross examination), it was a small piece of ...  Read Full »


Dr. Suvina Attavar

Answer: Hello, Welcome to icliniq.com. I have read your query and can understand your concern. Your histopathology report indicates a superficial type of basal cell carcinoma. This is a common form of skin cancer, often seen in older individuals, potentially due to chronic sun exposure or previous injuri...  Read Full »

I have a lesion that changes color frequently. What to do?

Query: Hi doctor, I have attached a photo for your reference. Is this sign dangerous? It started almost 20 years ago to become dark and it became to be lighter around 5 years ago. Two days ago, again I have noticed this transformation with a white surface and that is healing now. It is around 4 mm. Please ...  Read Full »


Dr. Atishay Bukharia

Answer: Hi, Welcome back to icliniq.com. Is there any complaint in it? How many such lesions are there?   Read Full »

Could delayed breast specimen testing affect the results?

Query: Hello doctor, If a breast specimen is sent to the laboratory for routine histopathology and the breast panel was delayed by three hours, will there be a problem in running the tests? Will the breast panel not be processed because of the delay?  Read Full »


Dr. Utkarsh Sharma

Answer: Hello, Welcome to icliniq.com. I understand your concern and will definitely help you out. A breast specimen should be kept in formalin fixative within one hour of resection for optimal immunohistochemistry (breast panel) results. The most recent guidelines for ER (estrogen receptor), PR (progeste...  Read Full »

Can we get a definitive diagnosis by a histopathological examination?

Query: Hi doctor, I have a few doubts regarding the pathology reports. Please clarify. It seems like advances in pathology is increasing diagnostic confidence. Can alcoholic liver disease biopsy result ever be 100% accurate by itself? Labeling something as "consistent with" could be a real problem for all ...  Read Full »


Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to icliniq.com. Histopathology examination by biopsy is the most confirmatory method for many pathological conditions. Hyperlipidemia can lead fatty liver condition, which can be because of alcohol as well. From histopathology examination, it can be surely said that whether it is an inf...  Read Full »

I scratched a mole with my nails. Do I need to be worried?

Query: Hi doctor, I scratched a mole with my nail. It is a tiny scratch, and I do not even know if it is a mole. It appeared a few years ago. Now, I am worried. I have also attached the photo of it. Can you please advise me if it is dangerous?  Read Full »


Dr. Gaurang Gupta

Answer: Hello, Welcome to icliniq.com. You should not have scratched the moleas scratching increase the chance of malignancy in otherwisebenign mole. Presently, what I can see is the erosion (attachment removed to protect patient identity), so at this stage, even dermoscopy would not be able to find out m...  Read Full »

Is amelanotic melanoma a lesion to be concerned?

Query: Hello doctor,Does this lesion in my lower back (pink) appear to be worrisome for amelanotic melanoma? It now appears flesh-colored. Pictures attached.  Read Full »


Dr. Atishay Bukharia

Answer: Hi, Welcome to icliniq.com. I have seen the pictures. (attachment removed to protect patient identity). Yes, they are looking like melanoma. Signs of vascularization in the previous nevus is suggestive of melanoma. Kindly consult a local dermatologist as dermoscopic and histological examination...  Read Full »

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