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Is ankylosing spondylitis genetic?

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Patient's Query

Hello doctor,

My maternal uncle, who is in his fifties, was diagnosed with ankylosing spondylitis a few years ago. I have been experiencing some lower back pain myself, and I am worried that I might be at risk as well.

  1. Does AS run in families?

  2. Is there a genetic test that could determine my risk?

  3. And if it turns out I have early signs of AS, what can I do to slow its progression? What triggers AS?

Kindly help.

Thank you.

Answered by Dr. Sugandh Garg

Education:

MBBS

Professional Bio:

Dr. Sugandh Garg is a qualified medical professional with an MBBS degree and an MD in Forensic Medicine, with significant experience as a COVID-19 expert. Since March 2020, he has been actively working with the government civil hospital COVID team, managing emergency cases and overseeing quarantine and isolation protocols. He has played a key role in supporting COVID-19 patients through structured treatment guidance and diet protocols, contributing to effective patient care during the pandemic.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

AS (ankylosing spondylitis) (a type of arthritis that causes inflammation in the joints and ligaments of the spine) has a genetic component and runs in families, with a particular association with the HLA-B27 gene (a common gene in people with certain types of arthritis and other inflammatory diseases).

Many people with AS carry this gene, but it is not guaranteed. You can ask your doctor about an HLA-B27 genetic test.

AS starts in young adulthood and causes inflammation primarily in the spine and sacroiliac joints (at the base of the spine), leading to stiffness and pain.

The symptoms commonly include lower back pain that worsens in the morning and improves with movement.

I suggest you get an MRI (magnetic resonance imaging) to check for early signs of inflammation.

Triggers of AS include:

  1. Infections.

  2. Immune system responses

Here, the progression can be slowed down by:

  1. Regular physical activity, especially stretching and low-impact exercises like swimming or yoga.

  2. Anti-inflammatory medications (NSAIDs) or biologics are prescribed to reduce pain and inflammation.

  3. Maintain good posture.

  4. Minimize strain on your back.

  5. Stand straight.

  6. Avoid prolonged sitting.

  7. Manage stress.

  8. Avoid smoking.

  9. Maintaining a balanced diet.

  10. A physical examination by a doctor in a hospital is a must.

Kindly consult a physician, discuss with them, and start taking the medications with their consent.

I hope this information will help you.

Kindly revert in case of queries.

Thank you.

Medically reviewed by iCliniq medical review team
Published At November 12, 2024
Reviewed At October 6, 2025

Education:

MBBS

Professional Bio:

Dr. Sugandh Garg is a qualified medical professional with an MBBS degree and an MD in Forensic Medicine, with significant experience as a COVID-19 expert. Since March 2020, he has been actively working with the government civil hospital COVID team, managing emergency cases and overseeing quarantine and isolation protocols. He has played a key role in supporting COVID-19 patients through structured treatment guidance and diet protocols, contributing to effective patient care during the pandemic.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Sugandh Garg is a qualified medical professional with an MBBS degree and an MD in Forensic Medicine, with significant experience as a COVID-19 expert. Since March 2020, he has been actively working with the government civil hospital COVID team, managing emergency cases and overseeing quarantine and isolation protocols. He has played a key role in supporting COVID-19 patients through structured treatment guidance and diet protocols, contributing to effective patient care during the pandemic.

This doctor is not available for online consultations on the platform anymore.

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