Common "Hla B27 Antigen" queries answered by top doctors | iCliniq

Hla B27 Antigen

HLA-B27 blood test helps to identify HLA-B27 antigen in the body. HLA B27 antigen stands for human leukocyte antigen B27. It is a protein present on the surface of white blood cells. This protein helps the body's immune system identify differences between healthy tissues and foreign substances causing infection.

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Can sacroiliitis affect my friend's future life?

Query: Hi doctor,A friend of mine, who is a 28-year-old female, had been diagnosed with sacroiliitis for five years. She had been on painkillers (Indocap) for three years, which she was taking on a daily basis. Then for a year, her doctor advised her to have maintenance doses of Remicade infusions and she ...  Read Full »

Dr. Puri Divya Inder

Answer: Hi, Welcome to This problem is called spondyloarthritis, and it is associated with a gene called HLA-B27. It is a chronic disease where there may be periods of relapses and remission. There may be a flare-up of disease during pregnancy or post-pregnancy. Otherwise, it generally do...  Read Full »

Does Adalimumab injection causes kidney dysfunction in HLA-B27 positive patients?

Query: Hello doctor, I am a 26-year-old male. I am HLA-B27 positive (hereditary issue). I am suffering from joint pains since the last 16 years, I generally use Ultracet to suppress the pain. I have undergone a resurfacing surgery before nine years. Since then I have not taken any treatment. I have visit...  Read Full »

Dr. Anshul Varshney

Answer: Hello, Welcome to You need to understand that every medicine has its side effects and it is not that everyone gets it. Important is treatment. Since your disease may get worse with the passing years, Adalimumab injections would help you in controlling your disease. It rarely affects the...  Read Full »

I am HLA-B27 positive. Will it affect my marriage?

Query: Hi doctor,I am a 29-year-old female. I got married recently. I am HLA-B27 positive patient with vitamin D deficiency (less than 8%). These days, I am suffering from severe back and shoulder pain. Sometimes, there is hip joint pain, and I am not able to sleep at night. Rarely, the pain remains throug...  Read Full »

Dr. Naval Mendiratta

Answer: Hi, Welcome to Your symptoms do match spondyloarthropathy. It is a sort of arthritis, usually common in males but 10 % of the females can get affected. The severity is not so much in women, though. Secondly, painkillers (I am not sure which you are taking) are a good drug to stop ...  Read Full »

I am a HLA B27-positive male. Will it pass to my children?

Query: Hello doctor, I am a 26-year-old, and I had hip resurfacing surgery eight years back. I am an HLA B27 positive, even my father is also positive. I have had joint pain for the last fourteen years. Now, I wish to know that if I marry and have children will this pass on to them? What measures should I...  Read Full »

Dr. Ashaq Hussain Parrey

Answer: Hello, Welcome to About 80 % of people with ankylosing spondylitis have HLA B27 positive, and only 1 to 4 % of people with positive HLA B27 develop ankylosing spondylitis. That means out of 100 people with positive HLA B27, only one to four can develop ankylosing spondylitis, and 96 t...  Read Full »

Does an increase in uric acid and creatinine levels indicate a damaged kidney?

Query: Hi doctor, I am a 42 year old male. From the past three months, I was suffering from typhoid. Now, I have pain in knees, sole, back, and wrist joints. The test reports show high sensitivity c-reactive protein (hs-CRP) 7.67, eGFR 68, folate 2, uric acid 7.7, creatinine 1.02, total cholesterol 211, tr...  Read Full »

Dr. Ashaq Hussain Parrey

Answer: Hello, Welcome to You mentioned that you had typhoid three months back, and now have features of large joint arthritis. With this profile, it seems to be reactive arthritis. If you have heel pain, which is more in the morning once you get up from the bed and put your feet on the ground,...  Read Full »

My wife has a labrum tear. Is surgery needed?

Query: Hello doctor, My wife has been diagnosed with a labrum tear. She is 37 years old. She wants to get a second opinion on the treatment options. Is surgery the only option available? Will not the labrum heal on its own? Currently, she is on ayurvedic treatment. I have attached a few files for your refe...  Read Full »

Dr. Ashaq Hussain Parrey

Answer: Hello, Welcome to I went through the copies of the investigations you posted (attachment removed to protect patient identity). My interpretations are as follows: 1. She has arthritis of the hip joint with features of sacroiliitis (inflammation of one or both of the sacroiliac joints)...  Read Full »

Can I donate blood with spondyloarthritis?

Query: Hello doctor,I am an 18-year-old female. Six months ago, I did some blood tests and my doctor said that I resulted positive for HLA-B27 and that she suspects me to have spondyloarthritis. But she did not explain to me things that I can or cannot do from now on. I take one tablet of vitamin D weekly ...  Read Full »

Dr. Rajiv Ranjan Kumar

Answer: Hi,Welcome to (SpA) is a group of disorders that predominantly affects (inflammation or arthritis) in the spine and lower limbs. The common diseases which come under SpA are ankylosing spondylitis, reactive arthritis, psoriatic arthritis, etc. HLA-B27 is a gene that is ...  Read Full »

Does my scan report suggest the cause of my low back pain?

Query: Hi doctor, I do not remember any spine trauma. I do have morning stiffness of greater than one hour with will become better with movement. I have this issue for the past seven years. My HLA-B27 is positive. Am I suffering from inflammatory spondyloarthropathy or ankylosing spondylitis? I have attach...  Read Full »

Dr. Vivek Chail

Answer: Hi, Welcome to The SI joints show minimal linear hyperintensity on STIR (short TI inversion recovery) sequence (attachment removed to protect patient identity). It is mild edema and not the usual findings which are seen in inflammatory spondyloarthropathy. Probably, it is in the ...  Read Full »

I have muscle pain near the chest inspite of having medications. Why?

Query: Hello doctor,I have muscle pain near the chest. I am having muscle pain near the chest for the last two to three months. I have done all the cardiac tests, and it is fine, then I consulted a rheumatologist, and she suggested some tests and medicine. It has been a month, and I am still having some pa...  Read Full »

Dr. Puri Divya Inder

Answer: Hello,Welcome to are right, and you have peripheral arthritis due to HLA-B27 positive. Your chest pain is due to enthesitis, and please feel free to query me in this regard. If your HLA-B27 is positive by PCR (polymerization chain reaction), that is a condition that can give rise to ...  Read Full »

My friend has been detected as HLA-B27 positive and she has back pain. What does it mean?

Query: Hello doctor, My friend has been detected as HLA-B27 positive and her ESR is 33. She has back pain for the last four years but recently she is feeling more pain. We took an x-ray of the lower spine and it appears normal. She is only 31 years old. There is no one in the family (maternal or pat...  Read Full »

Dr. Sharoff Lokesh Mohan

Answer: Hi, Welcome to I read your query and can understand your concern. This is suggestive of a condition called ankylosing spondylitis. In this, there will be stiffness of the joints and calcification of tendons. This disease can be treated but cannot be cured. I suggest you stop Dolo and...  Read Full »

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