What could a brain biopsy show in case of seizures, balance, and memory issues?

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Your report (attachment removed to protect the patient's identity) shows a large brain tumor (glioma), one of the most common brain tumors in this age group. The tumor is associated with some bleeding foci, which impacts the prognosis. The tumor is also IDH (isocitrate dehydrogenase) wild type which means no mutation in the IDH gene, a little worse than the mutant type. But the full molecular report is still pending. Kindly send the molecular test of biopsy, pathology, and MRI (magnetic resonance imaging) reports. The rest of your investigations are normal. If this tumor is surgically removed, then the prognosis is better. If not possible, then maximum debulking, followed by radiotherapy and some oral medicine, also prolongs life.

Hope this helps.

Thank you and take care.

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

1. Gliomas have no staging system. Rather it has a grading system from 1 to 4. Your report shows the grading between 2 to 3, with grade 1 being less aggressive and grade 4 very aggressive.

2. Ki 67 or MiB 1 is 5 %, which is better than above 10. The higher the score, the worse the tumor. It can act as a cellular factor for tumor development.

3. Your tumor MGMT methylation is not detected. So it is unmethylated, meaning it may respond to the oral anti-tumor medicine Temozolomide.

4. Atypia is moderate, which is better than severe atypia.

5, 5GFAP positive is an astrocyte marker and helps diagnose.

Treatment is based on radical or maximum debulking surgery followed by radiotherapy and oral anti-tumor medicine.

Hope this helps.

Thank you and take care.