Will marriage of sisters' grandchildren affect their child?

Hello,

Welcome to icliniq.com. The likelihood of abnormalities in offspring depends on whether the sisters are married to their cousins or if the parents of the grandchildren are cousins themselves. If there is a close blood relation in either of these scenarios, the chances of abnormalities increase with each successive generation. However, if neither of the previous generations had any blood relation, then the chances of genetic abnormalities in the offspring are generally very low.

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Welcome back to icliniq.com.

• The chances are relatively less, since both the parents, although were cousins got married outside of the family.

• The challenge, however, is to get the approximate risk by knowing the type of disease or congenital abnormalities.

• I would like you to know that there are three different patterns of inheritance, some of them are mitochondrial and that goes from mother to kids and others are X-linked and becomes a disease in the sons only.

• It would be very helpful if you could kindly explain which congenital abnormality are you looking for exactly.

Revert back with the doubts to an internal medicine physician online.