Is it right to have chemotherapy for stage IV invasive lobular carcinoma?

Hi,

Welcome to icliniq.com.

I have gone through the attachment (attachment removed to protect patient identity). Yes, it is appropriate to use chemotherapy at this juncture. The HER2 (human epidermal growth factor receptor 2) result is mentioned as equivocal. So please do a FISH test (fluorescence in-situ hybridization) to find out whether it is positive or negative. After chemotherapy, consider doing a maintenance hormonal therapy. Immunotherapy in breast cancer is still in infancy, and promising results are seen in triple negative breast cancer women. I will not suggest a clinical trial at this juncture.

Hello,

Welcome back to icliniq.com.

I read your query and can understand your concern.

1. Let us wait and see what FISH (fluorescence in situ hybridization) results show.

2. Genomic sequencing and testing are useful in adjuvant or curative settings to look at the efficacy of chemotherapy.

3. Immunotherapy is a new concept and has been explored in various cancers. To the best of my knowledge, triple-negative breast cancer is an area of promise.

4. There is no scientific backing for using immunotherapy in breast cancer in daily clinical practice for lobular cancer at this stage.

However, if you find ongoing trials, feel free to get enrolled.

Hope this helps.

Thanks and take care.