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How to manage withdrawal signs in smokers?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

My father is 58 and has been smoking since he was 18. He says he wants to quit, but always relapses after a week or two. He tried nicotine gum and patches, but did not stick with them. Are medications like Varenicline or Bupropion truly effective?

How do you manage withdrawal cravings and mood changes in long-time smokers? I am worried because his recent spirometry showed reduced lung function (FEV1 or FVC was 65 percent). What support systems or tools can make quitting stick for someone like him?

Please help.

Thank you.

Hello,

Welcome to icliniq.com.

I understand your concern.

Your father’s desire to quit smoking is a crucial first step, especially given his reduced lung function with an FEV1 (forced expiratory volume) or FVC (forced vital capacity) of 65 percent, indicating airflow limitation likely related to smoking. Medications like Varenicline and Bupropion have strong evidence supporting their effectiveness in improving quit rates compared to nicotine replacement alone.

Varenicline acts on nicotine receptors to reduce cravings and withdrawal symptoms, while Bupropion also helps with mood stabilization. Managing withdrawal cravings and mood changes involves a combination of pharmacotherapy, behavioral counseling, and support; combining these approaches significantly increases success.

Close follow-up is important to adjust medications and provide encouragement, particularly in long-term smokers who often face strong addiction and psychological triggers. Support systems such as structured smoking cessation programs, cognitive-behavioral therapy, and digital apps can help track progress and provide motivation.

Encouraging him to set a quit date, identify triggers, and develop coping strategies for cravings will also be helpful. Given his lung impairment, quitting now can slow further decline and improve symptoms, so integrating medical treatment with comprehensive support tailored to his needs will maximize his chances of sustained success.

I hope this helps.

Kindly follow up if you have more concerns.

Thank you.

Medically reviewed byiCliniq medical review team

Published At March 30, 2026
Reviewed AtMarch 31, 2026

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