Chemicluminescent microparticle immunoassay (CMIA) tests for p24 antigens and antibodies to HIV. So, it is a fourth generation test. It is most accurate three months after a risky exposure. It detects HIV earlier than an ELISA test.

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I got tested for HIV after seven months of exposure from a diagnostic center. Can these results be trusted?

Query: Hello doctor, After exposure, I got tested for HIV (the condom covered half of the penis after ejaculating inside). All tests were conducted after seven months of exposure. Most of them are rapid tests, and two are CMIA tests from a diagnostic center. My query is, are these test results reliable? ...  Read Full »

Dr. Parth R Goswami

Answer: Hello, Welcome to the Following is my opinion for your asked question. I have seen the attached reports (attachments removed to protect the patient's identity). All your HIV (human immunodeficiency virus) test reports with different methods are negative for HIV. Diagnostic centers ar...  Read Full »

Is testing for HIV after 77 days with a rapid test card conclusive?

Query: Hello doctor,I had a protected intercourse with a girl twice in a single day. After that, the girl and I tested HIV negative using the fourth generation CMIA at 66 days. I again tested at 77 days using the rapid card method and that was negative as well. Is it conclusive? Also, can deep lip kissing ...  Read Full »

Dr. Richa Agarwal

Answer: Hello, Welcome to I have read your query and understand your concern. Yes, the test is conclusive. Deep lip kissing transmits HIV (human immunodeficiency virus) through the saliva. Feel free to ask more information. Good luck. Regards. For further queries consult an obstetrician and g...  Read Full »

What are the reasons for mouth ulcers, sore throat, and canker sore on my gum after having sex with a CSW?

Query: Hello doctor, Please help me. I had sex with a CSW for the first time, two months back. First, we had oral and penetrative sex using a condom. Then we had oral sex without a condom. The first time, the girl helped me put the condom. But later, I put it myself, as it was the first time. I put it bac...  Read Full »

Dr. Suvash Sahu

Answer: Hi, Welcome to I have read your concern. The window period for HIV (human immunodeficiency virus) can last up to 12 weeks. HIV infection cannot be diagnosed during this period because antibodies to HIV have not developed during this period. The test most commonly used in th...  Read Full »

Will homeopathy allergy tablets alter the HIV combination test results?

Query: Hello doctor, I had intercourse with a commercial sex worker around one and a half years ago. I had an accidental touch of my penis with her vagina. I do not know if any of her fluid touched my penis. After that, we had protective intercourse from that date. I have taken many CMIA fourth-generation...  Read Full »

Dr. Ravinder Kaur Sachdeva

Answer: Hi, Welcome to The accidental contact which you mentioned comes in low-risk exposure. But, it is really good to know that HIV (human immunodeficiency) combination test is negative on the ninety-first day and the hundred and eighty-seventh day. The testing recommendations are to ge...  Read Full »

Please suggest if the CMIA test for HIV is conclusive.

Query: Hi doctor, Please suggest how far is CMIA test for HIV is conclusive at six months. Some say that three months are sufficient enough and a few say that six months is conclusive for 98% cases. Which is the truth? Which is the category who take more than three months for seroconversion?  Read Full »

Dr. Mansuri Uzzaif Usmangani

Answer: Hi, Welcome to CMIA (chemiluminescent microparticle immunoassay) also know as HIV-DUO test. It checks for two things, both antigen and antibody. So, this test is highly conclusive after six weeks, and at six months, it is very conclusive. Seroconversion means developing antibody agains...  Read Full »

How conclusive is HIV CMIA test result on 26th day?

Query: Hi doctor,I have taken an HIV CMIA test on the 26th day after a sexual encounter. The result came back negative. After that, I had protected sex. But I saw some blood on the inner parts of my partner. At that time, I had two pimples on my penis at the end. I am concerned about it. Does this HIV test...  Read Full »

Dr. Ravinder Kaur Sachdeva

Answer: Hi, Welcome to HIV (human immunodeficiency virus) test taken on the 26th day of post-exposure is quite assuring but a confirmatory HIV antibody test is required to be taken at three months of last exposure. You do not have any specific symptoms to diagnose HIV. Your present sympto...  Read Full »

Is CMIA better than ELISA?

Query: Hi doctor, My CMIA on 177th day was nonreactive with an index of 1.4. My second CMIA on 181st day was also nonreactive with an index of 0.8. These two were done at different places. If you compare ELISA and CMIA combo for HIV antibody testing, which is better? What is the maximum window period of ...  Read Full »

Dr. Prakash H. Muddegowda

Answer: Hi, Welcome to Based on your query and attached reports (attachment removed to protect patient identity), my opinion is as follows: CMIA combo - chemiluminescent microparticle immunoassay is better as it detects both antigens and antibodies, whereas, ELISA (enzyme-linked immunosorbent a...  Read Full »

Is a round-shaped HIV kit used in the CIMA method?

Query: Hello doctor, I am 38 years old. I got exposed seven months back and checked after 94 days for the Immunochromatic method, and the result is non-reactive for HIV 1 and 2. Later after six months and 25 days, when I went to COVID-19 treatment, they check again for HIV. In the reports, it was non-react...  Read Full »

Dr. Parth R Goswami

Answer: Hello, Welcome to Following is my opinion on your asked question. Your HIV testing was done with a rapid immunochromatographic test and not with CMIA (chemiluminescence micropartical immunoassay). The rapid test is also conclusive in ruling out HIV (human immunodeficiency virus). You ha...  Read Full »

Are both CMIA and CLIA tests for HIV reliable?

Query: Hi doctor, I want to enquire about the HIV test and window period. My last exposure was six months back with CSW. It was protected, but I did HIV test on the 45th day, 75th day, 96th day, 120th day, and 168th day of last exposure due to fear. They did HIV tri-dot test, and all are negative. It is a...  Read Full »

Dr. Parth R Goswami

Answer: Hi, Welcome to the I can understand your concern. I will solve your doubt, so do not worry. Any test, including antibody testing, is useful to rule out HIV after six weeks and three months. CLIA (Clinical laboratory improvements amendments) and CMIA (Chemiluminescence micropartical im...  Read Full »

Are sore throat and pain at the base of the penis signs of HIV?

Query: Hi doctor, I had unprotected sex, and after that, four weeks later, I got a CMIA combo test (fourth generation) done. It is non-reactive. Now I have a sore throat and nerve like pain at the base of my penis. What are the chances of getting positive? How accurate are the fourth generation tests afte...  Read Full »

Dr. Basti Bharatesh Devendra

Answer: Hi, Welcome to Thank you for the query. The fourth-generation HIV (Human immunodeficiency viruses) antibody test is almost considered conclusive after one-month exposure. But it would be better to go for an HIV antibody test after three months of exposure to have final, conclusive re...  Read Full »

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