Q. How can I get rid of severe depression with anxiety?

Answered by
Dr. Aditya Gupta
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 17, 2018 and last reviewed on: Nov 07, 2022

Hello doctor,

I have severe depression alternating with severe anxiety. I have tried many medicines. Currently, I am taking 40 gm of Prozac in the morning and 30 mg of Remeron at bedtime. But during the day, I am a nervous basketcase. No doctors will give me any Benzodiazepine for some reason. I have difficulty functioning enough to be productive and unable to enjoy anything in life. I need more help. I do not want to continue living this way. Earlier, I was on Buspar, Vistaril, Trazodone, Paxil, and Doxepin. Doxepin was the most helpful but did no good when I am awake. The laboratory tests performed were blood tests. Only triglycerides were elevated.



Welcome to

In my opinion, you can discuss with the treating psychiatrist the following options:

  1. Increasing dose of Prozac (Fluoxetine).
  2. Substituting Prozac with Prestiq (Desvenlafaxine), Wellbutrin (Bupropion) or Zoloft (Sertraline).
  3. You can also opt for concurrent CBT (cognitive behavioral therapy) sessions.

Practicing a relaxation technique like breath relaxation exercises daily shall help.

Hi doctor,

Thank you for your prompt response.

I have just one quick question. I have friends with similar issues and they have all been prescribed Xanax and say that it is a huge help for them. Why is Xanax not an option for me? I am aware of the risk of addiction. But I am very careful to take all my medications only as prescribed.



Welcome back to

Xanax (Alprazolam) or any other benzodiazepine can be used to treat anxiety for the short-term only because of addiction potential and CNS depressant effect. I do not know why it had not been considered in your particular case. But if given, it should be used only for the short term.

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