Why am I feeling low despite starting medications?

Question

Hello doctor,

I have been feeling low the past few months, not just sad, but like everything takes so much effort. I cannot focus at work, I sleep way too much, and I have lost interest in things that I usually love. I started Sertraline 50 mg about six weeks ago, and I am not sure it is helping yet. I have a few concerns:

How long does it usually take for antidepressants to start working?
Is it normal to have mild nausea and headaches after starting antidepressants, or should I ask my doctor about changing the medicine?
Does therapy really help in the long run?
Do people fully recover from major depression, or does it keep coming back?
Will I be able to feel like myself again one day?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I can understand how difficult and exhausting this must feel, especially when even simple daily tasks start to feel overwhelming. Your description sounds like symptoms of major depression, which can deeply affect motivation, concentration, and energy levels. It is good that you have already started Sertraline and are in therapy, as both medication and counseling together often provide the best chance for improvement.

Antidepressants like Sertraline usually take six to eight weeks to show full effect, though some people notice small early changes like better sleep or a slightly improved mood.
Since you are around the six-week mark, your doctor may wait a little longer or consider a small dose change if you are not improving enough.
Mild nausea and headaches are common in the first few weeks of treatment and often get better as your body adjusts. If these side effects continue or feel hard to manage, you should talk to your doctor rather than trying to change the medicine on your own.
Feeling empty or unable to enjoy things is a real part of depression, and it takes time and steady support to heal.
Many people fully recover from major depression, while some may have future episodes, but these can be managed better when recognized early.
Therapy, regular routines, physical activity, and staying connected with others all help improve recovery.
Improvement usually happens slowly, but reaching out for help is an important step. With time, treatment, and the right support, you can feel like yourself again.

I hope this helps you.

Thank you.