Q. How long will it take to show the effect of Desvenlafaxine?

Answered by
Dr. Seikhoo Bishnoi
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on May 03, 2016 and last reviewed on: Feb 13, 2020

Hi doctor,

I am a 42 years old male. I had low mood with anxiety problem around two years back. I was on Desvenlafaxine 50 mg ER tablet prescribed by GP. I took it for around eight months and felt better. Then I consulted my psychiatrist and told that I have only anxiety. So, he prescribed Clonazepam 1 mg and Alprazolam 0.5 mg in the morning and Nitrazepam 10 mg and Clonazepam 1 mg in the night and stopped Desvenlafaxine 50 mg ER tablet. I slowly tapered from first month itself to finally in around one year; I was on 0.25 mg Clonazepam in the morning and 2.5 mg Nitrazepam in the night, which I felt has same effect as I started. Later, I tried to come out of it without any medication, but I was feeling anxious. Actually, I felt better with Desvenlafaxine 50 mg ER tablet, compared to other anti-anxiety medicines. So, I asked my psychiatrist and he said start taking Desvenlafaxine 50 mg ER tablet. But, I do not have the same effect as I felt earlier. Now, it is almost seven weeks. I am taking 2.5 mg Nitrazepam in the night and occasionally, Clonazepam 0.5 mg or Alprazolam 0.25 mg or 0.50 mg when I feel more anxious. So, I want to be only on Desvenlafaxine 50 mg ER tablet as earlier. Should I wait for some more time? Or should I increase dose to 75 mg or 100 mg? I really appreciate your help. By the way, I feel more anxious only at traffic signal or sometimes waiting in line at grocery store or sometime anticipatory fear in going far from my home. Thank you very much for your help.



Welcome to

I can understand your concern.

Desvenlafaxine is a good antidepressant and anti-anxiety drug. The drug should be continued for long time to see its full effects.

Drugs like Benzodiazepines (Clonazepam, Alprazolam or Nitrazepam) can help to control anxiety symptoms immediately, but these drugs are not the definite treatment of anxiety.

High risk of tolerance and increased abuse potential are the main reasons that these drugs should not be taken regularly for more than four weeks.

It is good that you have started taking Desvenlafaxine again and the drug will help you to come out of the symptoms.

Currently, you are on 50 mg dose and in my opinion the dose should be increased to 100 mg per day to see more effects and to get better control of symptoms. So, you can increase the dose of the drug without worries.

Keep other drugs like Clonazepam and Alprazolam for use on SOS basis only (as and when necessary).

You continue Nitrazepam for some days and then gradually reduce the dose and stop the drug completely. Wait for at least four more weeks to see the effect.

For further information consult a psychiatrist online -->

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Do I need a drug other than Clonazepam to control non-stop panic attacks?

.. understand your concern. Anxiety and panic disorders are serious disorders and tend to recur. Clonazepam is a benzodiazepine drug and have good efficacy in controlling the symptoms of anxiety. The drug can control panic symptoms effectively but is...   Read full

Can anxiety and stress cause frequent urination?

I use to get those episodes every few months when I had stress but since I got the fear it might never go away I get it almost daily now ... Can anxiety cause polyuria like this clear urine when I am stressed ...   Read full

Mirap and Clonazepam prescribed for anxiety and depression, Is it fine to take?

Age 40Y, Male, minor knee pain sometime ,TAK Tak Sound when sit on kness, no injury , Family Heridatory , suggest precaution in diet or medicine for future   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Monkeypox Virus - Symptoms, Diagnosis, Treatment, Complications, and Prevention
Monkeypox is a zoonotic viral disease. This virus got its name as it was first noticed in laboratory monkeys in the late...  Read more»
Tomato Fever - Causes, Symptoms, Diagnosis, Treatment, and Prevention
Tomato fever is an unidentified and fast-spreading type of viral infection seen in young children. Scroll down to know m...  Read more»
Histrionic Personality Disorder - Causes, Signs, Symptoms, Diagnosis and Treatment
Histrionic personality disorder causes variations in the thinking ability of a person. Read this article to know more.  Read more»

Ask your health query to a doctor online?

Ask a Psychiatrist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.