Q. What can cause diffuse cerebral atrophy?

Answered by
Dr. Ashok Kumar Choudhary
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Oct 28, 2015 and last reviewed on: Oct 09, 2018

Hi doctor,

My sister is a 45 year old female. She had two episodes of unconsciousness. Her BP usually is normal at 80/58 mmHg and pulse 76 to 80 beats per minute.  We got an MRI done which showed diffuse cerebral atrophy with chronic ischaemic changes. MRA normal with no flow limiting significant stenosis. I have attached the reports. Please guide.



Welcome to

  • From the attached MRI report (attachment removed to protect patient identity) it seems that vascular pathology is the primary cause for the MRI changes in brain.
  • The current pathology indicates that she had poor blood supply for last few years. The reason may be hypotension or due to immune pathology as this is the most common cause at this age. This kind of changes can lead to vascular dementia which is quite problematic.
  • The change is difficult to reverse but it is important to prevent further damage. This can be done by proper control of blood pressure and blood thinning medications.
  • In addition, it is also essential to consult a neurologist to find out the cause of this problem and get it treated as soon as possible. Please see a neurologist in person for complete neurological examination.

For further information consult a neurologist online -->

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