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HomeAnswersInternal Medicinedoxylamine succinateIs taking 350 mg of Unisom safe or lethal?

Is taking 350 mg of Unisom safe or lethal?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At April 6, 2018
Reviewed AtJanuary 12, 2023

Patient's Query

Hello doctor,

My friend took a little more sleeping aid than usual (not suicidal) and I was wondering whether 350 mg of Unisom (Doxylamine succinate) is safe or lethal. He is showing signs of being super sleepy. He has a history of depression and drug addiction.


Welcome to icliniq.com.

The usual dose of Doxylamine succinate as an antihistamine will not exceed greater than 60 mg per day.

Excessive dose may cause CNS (central nervous system) depression, palpitations, tachycardia, disorientation, dizziness, drowsiness, headache, paradoxical central nervous system stimulation, vertigo, anorexia, constipation, diarrhea, dry mucous membranes, epigastric pain, xerostomia, dysuria, urinary retention, blurred vision and diplopia. So, there is no specific antidote treatment and symptomatic support may be required. If it is severe CNS depression, it can lead to coma. So, please consult your doctor immediately. He will examine and treat him accordingly.

For more information consult an internal medicine physician online --> https://www.icliniq.com/ask-a-doctor-online/internal-medicine-physician

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Penchilaprasad Kandikattu
Dr. Penchilaprasad Kandikattu

Internal Medicine

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