Patient's Query
Hi doctor,
My daughter, who is 28 years old, was diagnosed with cervical dystonia approximately two years ago, and her condition has recently worsened significantly. Her neck persistently twists toward the right side and slightly upward, accompanied by muscle spasms that are sufficiently painful to cause her to cry on occasion. She has undergone three rounds of botulinum toxin injections, which have provided relief for approximately two months each time; however, the dystonia returns with increased severity thereafter.
Her neurologist has prescribed Baclofen at a dosage of twenty milligrams three times daily, along with Clonazepam to be used during episodes of severe symptoms. Unfortunately, these medications cause substantial drowsiness, impairing her ability to perform her work effectively. The dystonia is negatively impacting her occupation as a teacher, as she is unable to maintain eye contact with her students and feels embarrassed about her physical appearance.
Her most recent magnetic resonance imaging (MRI) scan revealed no abnormalities, and her blood tests were within normal limits.
We have researched deep brain stimulation (DBS) as a treatment option for dystonia and would like to inquire whether this procedure could be suitable for her condition. Additionally, are newer treatments available that might provide more effective relief than Botulinum toxin injections?
It is noteworthy that her dystonia worsens with fatigue and stress. Furthermore, she has recently developed a tremor in her right hand.
Please help me.
Thanks.
Hi,
Welcome to icliniq.com.
I can understand your concern.
Current treatment considerations
Botulinum toxin injections are the first-line treatment for cervical dystonia. However, the wearing off of therapeutic effects after approximately two months may indicate suboptimal injection sites or dosages or the development of neutralizing antibodies.
New treatment options
Deep brain stimulation (DBS) is a valid therapeutic option that targets the globus pallidus. It is particularly beneficial for patients experiencing wearing-off effects or those who do not respond adequately to Botulinum toxin therapy.
Additional pharmacological treatments
Artane (Trihexyphenidyl) is effective, especially in younger patients, but may cause side effects related to mood alterations and memory impairment.
Tetrabenazine may provide symptomatic relief for dystonia but carries a risk of inducing depression.
Other therapeutic approaches
Utilization of physical and sensory tricks to manage symptoms.
Management of sleep disturbances and depression through pharmacological treatment or cognitive-behavioral therapy (CBT), among other modalities.
Experimental therapies
Gene therapy and stem cell transplantation (SCT) are currently under investigation in clinical trials and research studies.
Feel free to ask if you need any more clarification or help with your questions.
Was this conversation helpful?
Answered byDr. Muhammad Anees Ur Rehman
Medically reviewed byiCliniq medical review team
Same symptoms don't mean you have the same problem. Consult a doctor now!
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.