Gamma Globulin Level

Gamma globulins are the most abundant class of serum proteins after albumin. The main classes of gamma globulin are immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM). These antibodies protect us from various infections affecting our immune system.

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How to find the stage of multiple myeloma?

Query: Hi doctor, My 97 year old mother, who is in a nursing home, is more tired and feeling unwell. A blood test has shown she has likely got multiple myeloma. She had left-sided paralysis from a stroke six years ago. She cannot speak, and she is slow in understanding and writing, but she has no dementia...  Read Full »

Dr. Parth R Goswami

Answer: Hi, Welcome to Sorry to hear about your mother's condition. I have read all the test values that you have mentioned. From which, I can see that her total protein is high and albumin is low with elevated gamma globulin. Immunofixation electrophoresis is the best test to detect plasma ce...  Read Full »

Are the fluctuation in albumin and globulin values the cause for my black stools?

Query: Hello doctor,I am a 45-year-old male. My height is 5'5", and my weight is 75 kg. I have been passing black stool for several days. I consulted a doctor, and he did some blood investigations. It showed fluctuations in my serum aluminum and serum globulin values. What should I do now?Kindly help.  Read Full »

Dr. Zubayeralam

Answer: Hi, Welcome to Thank you for the query. I can understand your concern. According to your statement, you have been suffering from the passing of black stool. I saw the reports that you have sent (attachments removed to protect the patient’s identity). Passing of black stool is not a...  Read Full »

I have asthma, with a foul smell coming from my nose and throat. What to do?

Query: Hello doctor, I have allergic asthma and nasal polyp since the past year. I have seasonal asthma since my childhood, and during an endoscopy, they found a 7 mm polyp at the GE junction, which is benign. I am feeling fatigue, and some foul smell is coming from my throat and nose. My recent bloo...  Read Full »

Dr. Parth R Goswami

Answer: Hi, Welcome to the According to the history provided, you are having asthma and acid reflux disease. To cure asthma, I suggest using Salmeterol and steroid combination inhaler. Here steroid component can lead to throat irritation and secondary throat infection, for example, candidiasis ...  Read Full »

Can hypercoagulability occur with elevated globulin level?

Query: Hi doctor, My father is a 70-year-old male with BPH and well-controlled type-2 diabetes. He has been fatigued for six weeks. He was found three weeks ago to have mild anemia (Hb-12 gm/dL) and macrocytosis with a mildly low Vitamin B12. He started Vitamin B12 but had a slow progression of fatigue an...  Read Full »

Dr. Parth R Goswami

Answer: Hello, Welcome to Following is my opinion for your asked question. We cannot say multiple myeloma conclusively just now. Impaired kidney function also can cause anemia, fatigue, and low platelet count. Diabetes could have produced such renal dysfunction. However, serum immunofixatio...  Read Full »

Can low level of gamma gloublin affect HIV test result?

Query: Hello doctor, I had an unprotected relation two months ago, which led to urethritis three days after that was treated with a 10 days course of Levaquin. The urethritis disappeared, but at the end of the treatment, I started to feel neurological symptoms, numbness, tingling burning sensation in my ar...  Read Full »

Dr. Vedprakash Verma

Answer: Hello,Welcome to you have done all the test which came normal. Hiv antibodies while detecting in initial phase generally came negative, as it is in window period for three months. So have to recheck HIV antibody test post three months of exposure. And if it comes negative after then n...  Read Full »

What are the causes of increased blood protein levels?

Query: Hi doctor, I went to the doctor for a general physical examination and did the normal blood work. Everything came back normal, except my blood protein was 8.5 g/dL. She sent me for another blood test today, monoclonal protein test. I am worried sick until I get the test results. Should I be concer...  Read Full »

Dr. Sumit Srivastava

Answer: Hi, Welcome to Your protein level is in the upper normal range. Normal body proteins value can range from 6 to 8.5 g/dL. Increased proteins and monoclonal antibodies are seen in plasma cell disorders, but patients in such cases usually have a fever, back pain, anemia, and a myriad of o...  Read Full »

My blood protein levels are in higher range. Is that a precursor of any problem?

Query: Hi doctor, For around seven years, my blood protein levels range from 8 to 8.6. The average of all is 8.29 and nothing showed up in urine. Is this a precursor to something? When I have asked doctors, they all said that it was in guidelines and it is intermittent.  Read Full »

Dr. Prakash H Muddegowda

Answer: Hi, Welcome to Based on your query, my opinion is as follows: Yes, your doctor is right. Variation in protein levels is always present. Only, if the globulin levels are too high, then it is worrisome. If the globulin levels are increasing over time, then you need to be worried. If not, ...  Read Full »

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