What causes a high level of gamma in the liver while taking antiepileptic drugs?

Question

Hello doctor,

I have been sick with epilepsy in my brain for a long time and I used always the following treatments

1. Tegretol CR 400 twice a day.

2. Koprra 500 mg twice a day.

3. Lamitor 100 mg twice a day.

And I do tests at the laboratory every three months and all the results tests are good but the level of gamma in the liver is always high rate between (160 - 250), although the normal ratio of (0 - 50). Is there a drug to reduce the ratio of gamma in the liver?

Answer 1

Hello,

Welcome to icliniq.com

I read your query and understand your concern.

By gamma, do you mean by GGT? Among the mentioned antiepileptic medicines, tablet Tegretol (Carbamazepine) can cause alteration in hepatic enzymes. Increased SGOT (serum glutamic-oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) indicate hepatocellular injury, and increased ALP (alkaline phosphatase) or GGT indicates bile flow obstruction - cholangitis. I suggest you consult a gastroenterologist to look for other causes of high GGT. It can also be high in people who take alcohol. If high GGT (gamma-glutamyl transpeptidase) is drug-induced, then up to a level, it needs close monitoring. But if elevated above a certain level, there may be a need to withhold the medicine. I hope I have cleared your doubts.

Thank you.