Can liquid biopsy detect glioblastoma progression?

Question

Hello doctor,

I am a 56-year-old male recently diagnosed with glioblastoma after experiencing persistent headaches, memory issues, and vision changes. An MRI revealed a 4.5 cm mass in the right temporal lobe, and a biopsy confirmed the diagnosis. I have started radiation therapy and chemotherapy with temozolomide, but I am concerned about monitoring the progression.

My most recent blood test was normal, except for slightly elevated liver enzymes (ALT: 52, AST: 48). My oncologist mentioned the possibility of using a liquid biopsy to track tumor DNA in my bloodstream and monitor for early signs of recurrence.

Given the aggressive nature of glioblastoma, I am curious about how reliable liquid biopsy testing is for detecting tumor progression compared to regular imaging. Additionally, I would like to know if this approach could help tailor my treatment moving forward and whether there are other blood-based markers worth tracking.

Could you provide insights into this option and its potential benefits?

Please guide.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

Thank you for posting your query.

Monitoring glioblastoma involves:

Magnetic resonance imaging (MRI).
Liquid biopsy for early detection of tumor progression and recurrence.

Liquid biopsy is a non-invasive method that detects circulating tumor DNA (deoxyribose nucleic acid) (ctDNA) in the bloodstream, providing real-time cancer monitoring. This is particularly useful in glioblastoma, where recurrence is common, and imaging alone may not always identify early molecular changes.

Slightly elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels could be associated with chemotherapy using Temozolomide, which can sometimes irritate the liver. Your oncologist will monitor these enzymes closely.

Glial Fibrillary Acidic Protein (GFAP) is often elevated in gliomas.

A physical examination by your doctor in a hospital is essential.

Feel free to reach out with any additional questions or concerns about your treatment.

Wishing you a speedy recovery!

Please let me know if you want some help.

Thank you.