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As you have considered in history, surgery, radiation, and chemotherapy have been already given. The glioblastoma is a grade IV brain tumor so have overall poor outcomes even after best treatment. So if the disease is unresectable, consider for best supportive care at home. But if the patient's general condition is good, it is time to add a second line of chemotherapy. All these drugs are prescribed only after patient's clinical examination. So my humble request to please consider for local oncologist visit.