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Does Levofloxacin cure both chlamydia and gonorrhea?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At May 8, 2017
Reviewed AtNovember 6, 2023

Patient's Query

Hi doctor,

I did IgG (Immunoglobulin G) test for Herpes simplex virus (HSV-1 and HSV-2) after four months of possible exposure, which was negative. Is it conclusive? Is there any need to do IgM (Immunoglobulin M) test? If IgG is negative, can I consider that I am not infected?

Hello, Welcome to icliniq.com.

The time required for IgG (immunoglobulin G) antibodies to develop after the exposure to HSV (herpes simplex virus) is usually 21 to 42 days. A negative HSV IgG means that you have probably not been exposed to HSV. HSV IgM (immunoglobulin M) will tell whether you have an acute or current infection. These usually takes 9 to 10 days to develop after the infection and lasts for 7 to 14 days. If the high risk exposure was four months back and there had been no other exposure, HSV IgG will suffice. I will also suggest that if you had a high-risk exposure, get your rapid HIV (human immunodeficiency virus) antibody test done. Hope your query is answered, but if you have any other question, please revert.

Patient's Query

Hi doctor,

Thank you for replying. I have had an HIV (Human Immunodeficiency Virus) antibody test, which was negative. But my chlamydia IgG (Immunoglobulin G) is negative, and IgM (Immunoglobulin M) is weakly positive. I took Doxy 1 L-DR forte for seven days after this exposure. I also got a gram stain urine test for gonococci, which was negative. Now I am takingLevofloxacin 750 mg for ten days as per my doctor's advice. Is negative HIV antibody test and HIV PCR (Polymerase Chain Reaction) conclusive after four months? Is negative gram stain urine test for gonococci definitive after four months? Why is chlamydia IgG negative and IgM weakly positive? Will urine PCR for chlamydia and gonococci detect infection if we check on the eighth day after exposure? For PCR, the first urine was taken at 6 AM and handed over to the laboratory at 10 AM. Will this time lag interfere with the final result? I had sex with my wife only once after this incident, and I have checked her urine routine today, I am attaching the reports. Does it mean that she is also infected? Does routine urine culture detect chlamydia or gonorrhea?

Hi, Welcome back to icliniq.com.

I have seen your wife's report (attachment removed to protect patient identity). Answers to your queries are as follows. Yes, a negative HIV (Human Immunodeficiency Virus) antibody test along with PCR (polymerase chain reaction) test done at four months is highly conclusive. Yes, a negative gram stain urine test for gonorrhea is again conclusive at four months. Chlamydia IgM (Immunoglobulin M) weak positivity indicates recent chlamydia infection and after some duration, IgM will start waning and IgG will appear. It is possible to detect infection after eight days of exposure. This time lag is unlikely to affect PCR (Polymerase Chain Reaction). Your wife's routine urine examination is normal. She was not tested for gonorrhea infection. Gonorrhea and chlamydia require specific tests. Hope you have got answers to your queries, but if you still have any other query, please revert.

Patient's Query

Hi doctor,

Thank you for the reply. Will Levofloxacin 750 mg cure chlamydia? Will a throat swab PCR (Polymerase Chain Reaction) detect both chlamydia and gonorrhea? After completing Levofloxacin, when should I get retested? Does Levofloxacin cure both chlamydia and gonorrhea? In my wife's routine urine test the pus cells and epithelial cells are above normal. Does it mean she has any infection?

Hi, Welcome back to icliniq.com.

Levofloxacin 750 once a day for seven days will work for chlamydia. For chlamydia, a urine sample is given, and for gonorrhea, a throat swab is taken. Retesting is generally preferred at least after two weeks. Yes, Levofloxacin is used for both chlamydia and gonorrhea infections. Your wife's routine urine examination is normal. Hope your queries are answered, but if you still have any more questions, please revert.

Patient's Query

Hi Dr. Attaching the Urine PCR (Polymerase Chain Reaction) test of my wife on the 8th day of exposure. Can I consider this results are conclusive? Is testing on 8th day too soon for this tests? whether I need to test again? I have completed Levoflox 750 once a day for 10 days. What test I have to do now to check whether infection is eliminated or not? Earlier my IgM (Immunoglobulin M) was weakly positive. After taking medication if infection is eliminated then whether the IGM will become negative? hether I have to test IGG and IGM

Hi Rahul! Welcome again!

I could not see any attachment in this query. Testing or screening for Chlamydia can be done as early as 24 hours after the exposure. The incubation period varies and it is suggested for the most accurate results get tested two weeks after the exposure. If Chlamydia test is positive, it is suggested to repeat the test after 2 weeks of treatment completion so as to confirm that Chlamydial infection is cleared from the body. Chlamydia ELISA (Enzyme Linked Immunosorbent Assay), IgM (Immunoglobulin M) & IgG (Immunoglobulin G). Yes, IgM will slowly wane off and IgG will appear and this will indicate protective immune response and a past infection. Both to be tested again, as your earlier result was weakly reactive.

Patient's Query

--file attached--
No file attached dear!

Patient's Query

Hi Dr,I tried to attach the report but unable to do so. Following are the results of the urine PCR of my wife did on the 8th day of exposure Chlamydia Trachomatis, N.Gonorrea, Mycoplasma Genetalium, Treponema pallidum DNA PCR (Deoxyribonucleic acid Polymerase Chain Reaction), Gardnerella Vaginalis, Ureaplasm urealyticum/Pavum, Trichomonas Vaginalis. All are Negative and method is CE_IVD Approved real time PCR assay with high sensitivity and specificity Herpes Simplex Virus (HSV1/2) DNA-- Negative- method is CE_IVD approved molecular diagnostic test Relatime qualitative PCR detects both HSV 1 & 2 with higher sensitivity and specificity. Please tell whether this is conclusive? My urine gram stain test for gonorrea is negative.Whether I will be infect oral gonorrea if the person with whom I engaged is having gonorrea? That is only oral gonorrea not gential gonorrea?

Hi Rahul! Welcome back!The complete STD (Sexually Transmitted Disease) panel performed for your wife is conclusive. Gonorrhoea can be acquired from a person infected with it, during oral sex. The bacteria spreads through oral sex with an infected partner. If you had oral sex with that person, throat swab is preferred. Hope your query is answered, but please do not hesitate to ask or call for any doubts.Best wishes!

Patient's Query

Hi Dr

Suppose the person I engaged is having gonorrea and I am doing both inter course and oral whether I will be infect only oral gonorrea.I think If I do both act then I will infect genital as well as oral. I am asking this because my urine gram stain negative. I have engaged both oral as well as intercourse

Hi!Most men who are infected with Gonorrhoea shows symptoms within​ two to five days after exposure, with a possibility of manifestation upto 30 days. This could be in the form of yellow- white discharge from penis/ burning in the urine/ pain or swelling of testicles. Gonorrhoea infection of mouth is usually without symptoms. But if present, this includes soreness or redness in the mouth or throat. Throat swab culture test will help to determine the Gonorrhoea infection. The specimen choice depends on sexual orientation of person besides other factors. Urethral swab and or throat swab is preferred. Urine sample is one of the specimen type suitable for PCR (Polymerase Chain Reaction) test. Hope you have got answers to your query, but please feel free to ask or call.

Patient's Query

Hi Dr, Whether doing throat swab gram staining test detects oral gonorrea? Whether routine throat swab culture detects oral gonorrea? If both are not detect oral gonorrea then which test I have to do? For throat swab test any preparation I have to do before test?

Hi Rahul! Welcome to icliniq!Throat swab for Gonorrhoea is generally recommended in men who have sex with men and had oral sex. Gram stain is sensitive and specific for urethral sample but is not sufficient for throat sample. In addition to culture, NAAT (Nucleic acid Amplification Test) is also available. Yes. Although tests are very sensitive and specific and there is very small chance of being false Negative. In throat sample, back of the throat and tonsillar area is swabbed with a sterile swab. Swab is just like a cotton bud but is smaller and round in shape. No prior preparation is required. Hope your queries are answered, but feel free to ask any question.Best wishes!

Patient's Query

Hi Dr.Today I met my doctor and told about the oral gonorrhea (Not tested).He has given me Azee 500 mg 2 tabs to be consumed once (Injection is allergic to me) and cefixime 200mg twice daily for 1 week. Is it OK for oral gonorrhea (If I am affected). If I am doing routine Throat swab culture whether I need to tell lab to test oral gonorrhea specifically or just ask them to do routine culture and I can find the same in the result. If I am infected with oral gonorrhea what will be written in the throat swab culture report?

Hi!You have been given adequate treatment. If you have yet not started the treatment, wait for it, if you are planning to go for throat swab. If you have already started with it, inform the lab person about the medicines you are taking. You need to tell that you require throat swab culture for Gonorrhoea.Don't worry for report card. It will be given by designated lab person. It could be in the form of gram negative, oxidase positive diplococci isolated indicating Gonorrhoea or it can be Negative for it. Hope your questions are answered but you are always welcome to ask or call anytime.Best wishes!

Patient's Query

Hi DrAfter treatment of chlamydia which test I have to do whether it is Immunoglobulin(IgG and IGM) or can I do Urine PCR (Polymerase Chain Reaction)? Which is most appropriate? What about oral gonorrhea which test I have to do after treatment PCR of throat swab or Culture? As my gram stain urine test for gonorrhea is Negative after 4.5 months ,is it need to repeat the same again? What other STD (Sexually Transmitted Disease) tests I have to do? what about EBV (Epstein Barr Virus) and HPV (Human Papilloma Virus)?

Hi Rahul! Welcome!You can go for urine PCR (Polymerase Chain Reaction) for Chlamydia. PCR. No, you need not to repeat it. VDRL (Venereal Disease Research Laboratory) for syphilis (if it has not been done before). Just to highlight the fact that even if a partner has an STI (Sexually Transmitted Infection), it does not necessarily leads to transmission. The risk of transmission from a single exposure is not known. There is no point of worrying of HPV (Human Papillom Virus)/EBV (Epstein Barr Virus). There is no need to go for it. Hope I have answered your questions, but don't hesitate to ask or call anytime.Best wishes!

Patient's Query

Hi Dr After treatment of chlamydia how many days the burning sensation of penis exists? I have some small milky bubbles is seen in the lips especially in the corners. What may that? sometime my tongue looks white? Pls analyze this?

Hi!Get your routine urine examination as well as urine Culture sensitivity. There could be many causes. It requires proper examination. However, sending photos of lesions might be of some help. Best wishes!

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Ravinder K. Sachdeva
Dr. Ravinder K. Sachdeva

HIV/AIDS specialist

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