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I have lung nodules. Is it due to endometrial cancer recurrence?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have lung nodules with a history of endometrial cancer (Figo stage 2) 10 years ago. There is a slight increase and a slight decrease in the size of lung nodules in the span of three months. My CT biopsy, which was done three months ago, was inconclusive.

Please help.

Answered by Dr. Ali Osman

Hello,

Welcome to icliniq.com.

I understand your concern.

According to my understanding, the most likely considerations in this situation include:

  1. Metastatic recurrence of prior endometrial cancer.

  2. Primary lung nodules unrelated to the previous malignancy.

  3. Benign inflammatory or infectious nodules.

  4. Scar tissue or granulomatous disease.

Your history of FIGO (International Federation of Gynecology and Obstetrics) stage II endometrial cancer increases concern for possible late metastasis, even after ten years, although late recurrence is less common.

Pulmonary nodules that slightly increase and decrease in size over a three-month interval can sometimes suggest inflammatory or infectious etiologies rather than classic metastatic disease, as metastases typically demonstrate progressive growth.

An inconclusive CT (computed tomography)-guided biopsy indicates that the sampled tissue did not clearly demonstrate either malignant or benign pathology. This can occur when the lesion is small or when tissue sampling is limited or nonrepresentative.

The next step usually includes short-interval repeat imaging, PET-CT (positron emission tomography-computed tomography) to assess metabolic activity, or repeat biopsy, potentially using a different technique such as navigational bronchoscopy or surgical biopsy, depending on the size and location of the nodules.

A definitive diagnosis cannot be established without adequate tissue confirmation.

Current working diagnosis is indeterminate pulmonary nodules in a patient with prior endometrial carcinoma; rule out metastatic disease.

I hope this helps.

For more queries, feel free to reach out to me anytime. I am here to help you.

Thank you.

Answered byDr. Ali Osman

Medically reviewed byiCliniq medical review team

Published At May 19, 2026
Reviewed AtMay 19, 2026

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Ali Osman
Dr. Ali Osman

Obstetrics and Gynecology

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