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Should I stop Lurasidone due to restlessness and insomnia?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I have been using Lurasidone for nine days now and would like to know whether it is okay to discontinue its usage. The reason being that I am having various side effects such as restlessness, insomnia, a feeling of doom, excessive urination, and inability to urinate. Can you tell me what to do?

Any help in this regard will be appreciated.

Thank you very much.
Answered by Dr. Emad Mohammed

Education:

MBBS

Professional Bio:

I am a dedicated physician and medical educator with nearly a decade of experience across diverse healtcare settings including emergency medicine, critical care, general practice and academic teaching. My medical foundation includes an MBBS and an MD in Pharmacology, which allows me to approach patient care with a deep expertise in rational drug therapy and precise medication management. Throughout my career, I have managed a wide spectrum of health concerns, from life threatening conditions as a Resident Emergency Physician to the long term management of chronic illnesses like diabetes and hypertension as a general practitioner. My clinical approach is deeply rooted in preventive medicine, I am passionate about educating my patients on lifestyle and therapeutic strategies to prevent disease onset and significantly improve their long term healthspan. I pride myself on delivering empathetic, high-quality care through digital interfaces. I have successfully managed chronic conditions and acute medical needs via tele-consultations for several years, always with a focus on patient education. By providing accessible medical advice and focusing on disease prevention, I aim to equip my patients with the tools they need to achieve better health outcomes and a higher quality of life.

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Hi,

Welcome to icliniq.com.

I appreciate your concern.

Thank you for contacting us.

It is clear from what you have written that these symptoms must be causing you discomfort while being under treatment with lurasidone. Lurasidone is an atypical antipsychotic drug, used mainly for treating diseases like schizophrenia and bipolar disorder. The symptoms that you have mentioned restlessness, insomnia, impending doom, and changes in urination have been observed in some people taking this medicine.

As you have been taking this medicine for just nine days, it seems highly unlikely that you would have any withdrawal symptoms once you discontinue the drug. Yet, it will be wise to consult your treating physician at the earliest about this. Your doctor will help you decide whether discontinuing the drug is necessary for you or not. Also, if discontinuation is the need of the hour, then he or she will assist you in shifting to another line of treatment so that the disease stays controlled.

It might be sensible for you to consult a physician in case you still experience these symptoms after discontinuing the drug, especially the more serious ones of restlessness, difficulty sleeping, fear or unease, or urination problems. There could be other causes of these symptoms as well.

I hope that I have answered your questions.

Thank you.

Medically reviewed by iCliniq medical review team
Published At July 21, 2026
Reviewed At July 22, 2026

Education:

MBBS

Professional Bio:

I am a dedicated physician and medical educator with nearly a decade of experience across diverse healtcare settings including emergency medicine, critical care, general practice and academic teaching. My medical foundation includes an MBBS and an MD in Pharmacology, which allows me to approach patient care with a deep expertise in rational drug therapy and precise medication management. Throughout my career, I have managed a wide spectrum of health concerns, from life threatening conditions as a Resident Emergency Physician to the long term management of chronic illnesses like diabetes and hypertension as a general practitioner. My clinical approach is deeply rooted in preventive medicine, I am passionate about educating my patients on lifestyle and therapeutic strategies to prevent disease onset and significantly improve their long term healthspan. I pride myself on delivering empathetic, high-quality care through digital interfaces. I have successfully managed chronic conditions and acute medical needs via tele-consultations for several years, always with a focus on patient education. By providing accessible medical advice and focusing on disease prevention, I aim to equip my patients with the tools they need to achieve better health outcomes and a higher quality of life.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Emad Mohammed
Dr. Emad Mohammed

General Practitioner

Education:

MBBS

Professional Bio:

I am a dedicated physician and medical educator with nearly a decade of experience across diverse healtcare settings including emergency medicine, critical care, general practice and academic teaching. My medical foundation includes an MBBS and an MD in Pharmacology, which allows me to approach patient care with a deep expertise in rational drug therapy and precise medication management. Throughout my career, I have managed a wide spectrum of health concerns, from life threatening conditions as a Resident Emergency Physician to the long term management of chronic illnesses like diabetes and hypertension as a general practitioner. My clinical approach is deeply rooted in preventive medicine, I am passionate about educating my patients on lifestyle and therapeutic strategies to prevent disease onset and significantly improve their long term healthspan. I pride myself on delivering empathetic, high-quality care through digital interfaces. I have successfully managed chronic conditions and acute medical needs via tele-consultations for several years, always with a focus on patient education. By providing accessible medical advice and focusing on disease prevention, I aim to equip my patients with the tools they need to achieve better health outcomes and a higher quality of life.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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