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How long do I need treatment for a MAC lung infection?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello, Doctor.

I am a 54-year-old lady patient who is currently suffering from Mycobacterium avium complex (MAC) lung infection. My symptoms include coughing, fever, and a loss of weight by 11.02 pounds in the last three months. My CT scan showed that I suffer from nodular bronchiectasis. Currently, I am on antibiotics such as Azithromycin, Rifampin, and Ethambutol, but I get nauseated and fatigued due to these drugs.

  1. How long will this course of treatment continue?

  2. Will there be resistance develop in the bacteria?

  3. Would there be any benefit if I use inhaled bronchodilators or chest physiotherapy?

I am worried whether this disease can recur after treatment.

Kindly help.

Answered by Dr. Prakashkumar P Bhatt

Education:

MBBS

Professional Bio:

Dr. Prakashkumar P. Bhatt is a dedicated Neurologist committed to providing comprehensive care for patients with neurological conditions. He is skilled in diagnosing and managing a wide range of disorders, combining clinical expertise with a compassionate approach to treatment. Known for his clear communication and patient-centered care, Dr. Bhatt focuses on creating personalized treatment plans that support better health outcomes and improved quality of life.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

Your worries are justified. Infection with Mycobacterium avium complex is a slowly developing lung infection that usually occurs in patients with bronchiectasis and is characterized by chronic coughing, weight loss, tiredness, and fever.

The therapy is a long one. Normally, the Azithromycin, Rifampin, and Ethambutol combination is continued for at least 12 months after sputum cultures become negative. This often translates into a treatment duration of 12 to 18 months and even longer.

Nausea and weakness are among common side effects. Medicine intake together with food (if permitted), regular monitoring of liver function, and proper dose adjustment will be helpful. Always notify your physician about severe symptoms.

Resistance may arise if you:

• Medications are not taken on time.

• Only one drug is taken.

• Doses are irregular.

This is why triple therapy is crucial, and the importance of adherence cannot be overstated. Airway clearance is also essential. Chest physiotherapy, breathing techniques, and mucus clearance equipment are very effective. Inhalation of bronchodilators might be helpful if airways are narrowed. Mucus clearance leads to decreased bacterial burden.

Relapse is quite possible, particularly among patients with bronchiectasis. Regardless of successful treatment, constant monitoring is required. Yet, there are many patients who go through the course of treatment successfully.

The main aspects are the following:

• Adherence to therapy.

• Sputum monitoring.

• Monitoring of liver and eyes (Ethambutol).

• Nutritional support.

• Airway clearance exercises.

It is a chronic but controllable problem. When proper treatment is done over time, many people stabilize, put on weight, and become strong again.

I hope that you are happy with my response.

If you have any other questions, you may talk to me at iCliniq.

Thank you.

Medically reviewed by iCliniq medical review team
Published At June 1, 2026
Reviewed At July 13, 2026

Education:

MBBS

Professional Bio:

Dr. Prakashkumar P. Bhatt is a dedicated Neurologist committed to providing comprehensive care for patients with neurological conditions. He is skilled in diagnosing and managing a wide range of disorders, combining clinical expertise with a compassionate approach to treatment. Known for his clear communication and patient-centered care, Dr. Bhatt focuses on creating personalized treatment plans that support better health outcomes and improved quality of life.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Prakashkumar P. Bhatt is a dedicated Neurologist committed to providing comprehensive care for patients with neurological conditions. He is skilled in diagnosing and managing a wide range of disorders, combining clinical expertise with a compassionate approach to treatment. Known for his clear communication and patient-centered care, Dr. Bhatt focuses on creating personalized treatment plans that support better health outcomes and improved quality of life.

This doctor is not available for online consultations on the platform anymore.

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