Can Progesterone be used to treat meningioma?

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Hormone therapy with progestogens is one of the treatment options used in managing certain types of brain tumors, including meningiomas. Meningiomas are tumors that arise from the meninges, a protective membrane surrounding the brain and spinal cord. These tumors can express hormone receptors, particularly progesterone receptors, which means they respond to hormonal manipulation.

These hormones exert their effects by binding to progesterone receptors on tumor cells, thereby inhibiting their growth and proliferation. The effectiveness of hormone therapy with medroxyprogesterone acetate (MPA) may be considered in cases where meningiomas are slow-growing, hormone receptor-positive tumors that are not amenable to surgical resection or radiation therapy. While hormone therapy may not lead to complete tumor regression, it may help slow tumor growth and stabilize the disease, potentially improving symptoms and quality of life for some patients. The effectiveness varies from person to person.

Some side effects are weight gain, fluid retention, breast tenderness, irregular menstrual bleeding, mood changes, and long-term osteoporosis (a bone disease that develops when bone mineral density and bone mass decreases). Surgical resection and radiation therapy can be proposed as alternative treatments. However, the choice of treatment is the decision of your health provider based on your examination.

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