I did not get my period for a few months with rapid weight gain. Please help.

Hello,

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I just read your query. There are three differential diagnoses such as drug-induced Cushing syndrome, polycystic ovarian syndrome, and pregnancy. For Cushing's syndrome, do 24-hour urinary free cortisol, low dose Dexamethasone suppression test is suggested, if positive, then high dose Dexamethasone suppression test is recommended. For polycystic ovarian syndrome diagnosis, ultrasound pelvis, LH (luteinizing hormone), FSH (follicle-stimulating hormone) ratio, testosterone levels, and TSH (thyroid stimulating hormone) are recommended. For pregnancy, a serum beta hCG (human chorionic gonadotropin) test is recommended. Once these tests are done, the diagnosis will be clear. I hope this helps.

Hello,

Welcome back to icliniq.com.

Yes, if the offending drug has been stopped and still, the symptoms mentioned persist. The cortisol levels remain high, then it can still be Cushing's, and the type of Cushing's has to be identified using the low dose Dexamethasone suppression test and high dose Dexamethasone supression test as well to rule out the pituitary cause, adrenal cause, or ectopic cause. Also, alcohol consumption and PCOS cannot be ignored here.