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No period for months with rapid weight gain. Please help.

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am an 18-year-old female. I have a history of rapid weight gain over 3 months with severe stretch marks over the breasts, fullness around the face, and the upper body. At the time of blood work, I was taking a low-dose birth control pill (Blisovi 24 Fe) and a multivitamin and biotin. I continued taking biotin for some hair loss. But I stopped both after having my blood test. I did not get my period until now.

Please help.

Thank you.
Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

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Hello,

Welcome to icliniq.com.

I just read your query. There are three differential diagnoses: drug-induced Cushing syndrome, polycystic ovarian syndrome, and pregnancy. For Cushing's syndrome, a 24-hour urinary free cortisol low-dose Dexamethasone suppression test is suggested; if positive, then a high-dose Dexamethasone suppression test is recommended. For polycystic ovarian syndrome diagnosis, an ultrasound of the pelvis, LH (luteinizing hormone), FSH (follicle-stimulating hormone) ratio, testosterone levels, and TSH (thyroid-stimulating hormone) are recommended. For pregnancy, a serum beta hCG (human chorionic gonadotropin) test is recommended. Once these tests are done, the diagnosis will be clear.

I hope this helps.

Thank you.

Patient's Query

Hi doctor,

Thank you for the excellent and detailed response.

Can it become Cushing's if I do not take any medication?

Please help.

Thank you.

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Hello,

Welcome back to icliniq.com.

Yes, if the offending drug has been stopped and still, the symptoms mentioned persist. The cortisol levels remain high, then it can still be Cushing's, and the type of Cushing's has to be identified using the low dose Dexamethasone suppression test and high dose Dexamethasone supression test as well to rule out the pituitary cause, adrenal cause, or ectopic cause. Also, alcohol consumption and PCOS cannot be ignored here.

I hope this clarifies your concern.

Please feel free to reach out if you have any further questions.

Have a great day ahead.

Medically reviewed by Dr. Vinodhini J.
Published At October 4, 2020
Reviewed At May 4, 2026

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Education:

BDS

Professional Bio:

Dr. Vinodhini J. is a Dental Surgeon with extensive years of clinical experience. She specializes in the diagnosis, prevention, and treatment of dental and oral health issues, including restorative, surgical, and cosmetic procedures. With a patient-centered approach, she focuses on maintaining oral health, alleviating discomfort, and enhancing smiles. Her expertise ensures comprehensive care tailored to each patient’s dental needs and overall wellbeing.

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Consult other doctors in the same speciality

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Shaikh Sadaf
Dr. Shaikh Sadaf

Endocrinology

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology dedicated to providing comprehensive care for patients with hormonal and metabolic disorders. With two decades of clinical experience, she is skilled in managing diabetes, thyroid conditions, and a wide range of endocrine issues. Having trained internationally and earned prestigious memberships from leading medical colleges, Dr. Sadaf combines global expertise with a compassionate, patient-centered approach. She focuses on personalized treatment, preventive care, and long-term wellness to help patients achieve better health outcomes.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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