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What causes high B12 level in a person with MTHFR mutation?

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Patient's Query

Hello doctor,

I have genetic mutation MTHFR. I am on thyroid for hypothyroidism. My B12 level is 1476, the normal range is between 138 to 652 pmol/L. How can I lower my B12 level? Is this level a cause for concern? All the other blood levels are normal other than WBC which is at 3.4 and neutrophils which are at 1.2.
Answered by Dr. Elina Angelova Beleva

Education:

MD

Professional Bio:

Dr. Elina Angelova Beleva is a General Practitioner specializing in Hematology, with expertise in diagnosing and managing blood-related disorders. She is skilled in the diagnosis and treatment of anemia, clotting disorders, and leukemia. She can monitor and manage blood cancers and related therapies. She can interpret laboratory tests, including complete blood count (CBC) and bone marrow analysis. She can manage nutritional deficiencies and blood disorders. She can give chronic disease care and patient counseling. She can treat infection-related blood complications.

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Hello,

Welcome to icliniq.com.

It is essential to know the primary reason for vitamin B12 testing. Was it done due to any complaints that could be related to anemia like fatigue, malaise, or any other symptoms that could be related to thrombotic complications possibly due to the inherited MTHFR (methylenetetrahydrofolate reductase) mutation?

With the inherited MTHFR mutation, it is safe to maintain optimal levels of vitamin B12 rather than the lower ones. However, elevated levels of vitamin B12 and slight leukopenia associated with neutropenia should prompt further testing to exclude myelodysplastic syndrome.

A review of the peripheral blood smear by a hematologist or a hematopathologist is advisable together with a comprehensive review of your primary complaints and complete blood count values.

Medically reviewed by iCliniq medical review team
Published At June 4, 2018
Reviewed At July 9, 2026

Education:

MD

Professional Bio:

Dr. Elina Angelova Beleva is a General Practitioner specializing in Hematology, with expertise in diagnosing and managing blood-related disorders. She is skilled in the diagnosis and treatment of anemia, clotting disorders, and leukemia. She can monitor and manage blood cancers and related therapies. She can interpret laboratory tests, including complete blood count (CBC) and bone marrow analysis. She can manage nutritional deficiencies and blood disorders. She can give chronic disease care and patient counseling. She can treat infection-related blood complications.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

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Companion

High B12, MTHFR Mutation, and Low White Blood Cells Companion

How it works

If you have an MTHFR gene mutation and high vitamin B12 levels, it's important to understand what this means for your health. This section explains the key aspects.

1

MTHFR
Mutation

2

Vitamin
B12

3

High
Levels

4

Watch
Symptoms

5

Significance
Low

6

Next
Steps

This information is based on general medical guidance. It is not a substitute for professional medical advice; consult a qualified clinician.

Always consult a doctor before taking medication; self-medication carries serious health risks. Take exact prescribed doses, and never start, change, or stop treatment without medical supervision.
Dr. Elina Angelova Beleva
Dr. Elina Angelova Beleva

Hematology

Consult this doctor

Education:

MD

Professional Bio:

Dr. Elina Angelova Beleva is a General Practitioner specializing in Hematology, with expertise in diagnosing and managing blood-related disorders. She is skilled in the diagnosis and treatment of anemia, clotting disorders, and leukemia. She can monitor and manage blood cancers and related therapies. She can interpret laboratory tests, including complete blood count (CBC) and bone marrow analysis. She can manage nutritional deficiencies and blood disorders. She can give chronic disease care and patient counseling. She can treat infection-related blood complications.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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