Common "Myelodysplastic Syndrome" queries answered by top doctors | iCliniq

Myelodysplastic Syndrome

The myelodysplastic syndrome refers to a group of disorders in which the blood cells in the bone marrow remain immature and do not convert into healthy blood cells. The cause of some diseases is unknown, but for others, it may be due to a response to cancer therapy. Symptoms include fatigue, shortness of breath, paleness, and easy bruising. Treatment involves managing the symptoms with medication and blood transfusions.

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Is there a way to know the cause of increased CRP and WBC with just blood tests?

Query: Hello doctor,I need some follow-up information about a 77-year-old cousin diagnosed with JAK2 myeloproliferative and myelodysplastic neoplasm two years ago. He is being treated by a hematologist and gets consultation from his family physician. Unfortunately, he had several infections over the past y...  Read Full »

Dr. Abdul Aziz Khan

Answer: Hello, Welcome to It is confirmed by relevant history suggestive of infection. Immunophenotyping of peripheral blood or bone marrow is required to rule out acute transformation. So, you should consult a hematologist to make a proper diagnosis. Regards.  Read Full »

How serious can my RAEB condition lead?

Query: Hi doctor, I am writing to you regarding the health status of an elderly person. She is 85 years old and still in pretty good condition. Her current cardiological status is rated to be very well with no diabetes or any other medical issues. But from last year she shows a myelodysplastic syndrome. A ...  Read Full »

Dr. Muhammad Majid Hanif

Answer: Hi, Welcome to I have carefully worked through your case and want to assure you that proper care and expert opinion will be extended. When there is a hematology report which questions the quality of the biopsy specimen, we cannot just comment on the outcome of the test or what should...  Read Full »

Kindly suggest the physical changes seen in the acute transformation of myelodysplastic disorder.

Query: Hi doctor,An elderly family member was diagnosed with overlap myeloproliferative or myelodysplastic disorder two years back. He is being treated by a hematologist who arranges regular blood tests and he is said to be "hematological stable". However, I understand that there can be an acute transforma...  Read Full »

Dr. Mubashir Razzaq Khan

Answer: Hi, Welcome to I hope you are doing well in the pandemic. The acute transformation has clinical signs and symptoms of acute leukemia, such as recurring fever not responding to antibiotics, pallor, dyspnea, shortness of breath due to low hemoglobin, bruising and bleeding due to low pla...  Read Full »

Does a positive JAK 2 test indicate malignancy?

Query: Hi doctor, May I please have your opinion about the downloaded pathology results taken during a hospital admission? A couple of years earlier, there was a firm diagnosis of JAK 2 overlap myeloproliferative or myelodysplastic disorder. In your view, do the pathology results indicate an acute transfo...  Read Full »

Dr. Mohite Aniket Balasaheb

Answer: Hi, Welcome to I am sorry to say that the reports you have updated are, unfortunately, a document of COVID-19 (coronavirus disease 2019) information. Can you please give me more information about the same and send your detailed CBC (complete blood count) and marrow reports with JAK 2 ...  Read Full »

What is myeloproliferative neoplasm overlap syndrome?

Query: Hi doctor, My relative has myelodysplastic syndrome or myeloproliferative neoplasm overlap syndromes. He was told that if the disorder takes an acute transformation, then it may be life-threatening. However, could you please tell me if there is some other way (or some other stage) in which the disor...  Read Full »

Dr. Mubashir Razzaq Khan

Answer: Hi, Welcome to Myelodysplastic syndrome or myeloproliferative neoplasm are a collection of disorders, singly or collectively called so. The life threat depends on chromosomal abnormalities, the number of blast cells (highly doubling cells), the number of lineages involved, and cytopen...  Read Full »

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