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Is stem cell therapy worth trying for osteoarthritis at 52?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am frustrated with 3 years of knee pain from osteoarthritis. I tried everything, including physical therapy, cortisone, and hyaluronic acid injections.

My orthopedist is pushing for knee replacement, but I am only 52. I saw an advertisement for stem cell therapy claiming it regrows cartilage naturally without surgery. They harvest cells from my bone marrow, then inject them the same day.

It is too good to be true.

  1. In simple language, what are these stem cells actually doing in my knee if I get this?

  2. Is it worth trying before major surgery?

My sister says it is experimental and dangerous, but testimonials look amazing. I need honest advice.

Please help.

Thank you.

Answered by Dr. Abhilash C S

Education:

MS Ortho

Professional Bio:

Dr. Abhilash. C. S. is a dedicated Orthopedician with seven years of clinical experience. He completed his MBBS from Manipal Academy of Higher Education, followed by an MS in Orthopedics from Kaloji Narayana Rao University of Health Sciences and a DNB from the National Board of Examinations. Specializing in musculoskeletal conditions, he provides expert care through surgical and non-surgical treatments, helping patients restore mobility and improve their quality of life with precision and compassionate medical care.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I have read your query and understand your concern.

From your history, it does sound like you are dealing with ongoing knee pain related to osteoarthritis. I can understand why you feel frustrated, especially after trying physical therapy, cortisone injections, and hyaluronic acid injections without getting lasting relief.

Many people in their early 50s also feel hesitant about moving straight to knee replacement surgery, so your concerns are completely understandable. The treatments you have already tried can help reduce symptoms for some time, but they are generally not considered a substitute for knee replacement when the arthritis becomes more advanced.

Stem cell therapy has shown some promising results, but how well it works usually depends on the grade or stage of osteoarthritis. In earlier stages, some patients do notice improvement in pain and mobility.

However, if the arthritis is already severe with significant cartilage loss, the results may be limited, and knee replacement is often the more reliable option.

The idea behind stem cell therapy is that the injected cells may help reduce inflammation and support healing inside the joint.

Recovery is usually quicker compared to surgery, and there are generally not many side effects reported. That said, results can vary from person to person. You can still consider giving stem cell therapy a shot before deciding on knee replacement.

I hope this helps.

Thank you.

Medically reviewed by iCliniq medical review team
Published At May 14, 2026
Reviewed At May 18, 2026

Education:

MS Ortho

Professional Bio:

Dr. Abhilash. C. S. is a dedicated Orthopedician with seven years of clinical experience. He completed his MBBS from Manipal Academy of Higher Education, followed by an MS in Orthopedics from Kaloji Narayana Rao University of Health Sciences and a DNB from the National Board of Examinations. Specializing in musculoskeletal conditions, he provides expert care through surgical and non-surgical treatments, helping patients restore mobility and improve their quality of life with precision and compassionate medical care.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Abhilash  C S
Dr. Abhilash C S

Orthopedician and Traumatology

Education:

MS Ortho

Professional Bio:

Dr. Abhilash. C. S. is a dedicated Orthopedician with seven years of clinical experience. He completed his MBBS from Manipal Academy of Higher Education, followed by an MS in Orthopedics from Kaloji Narayana Rao University of Health Sciences and a DNB from the National Board of Examinations. Specializing in musculoskeletal conditions, he provides expert care through surgical and non-surgical treatments, helping patients restore mobility and improve their quality of life with precision and compassionate medical care.

This doctor is not available for online consultations on the platform anymore.

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