PAPP-A or PAPPA or pregnancy-associated plasma protein A is used in the prenatal screening of Down syndrome. Low level of this protein is used as a biochemical marker in prenatal testing.

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My double marker test report is abnormal. Is my baby healthy?

Query: Hi doctor, I had my nuchal translucency scan and double marker blood tests taken a few days ago. I am worried because my NT scan reports are normal, but my double marker test report shows a high risk for trisomy 21. All reports are attached for your guidance and suggestions. Kindly help.  Read Full »

Dr. Balakrishnan. R

Answer: Hi, Welcome to I hope you are doing well. I read your query, and I can understand your concern. From your history and reports (attachments removed to protect patient\'s identity), I gather that you are 33 years old, which is a low-risk age, and there are no other risk factor...  Read Full »

What are the pregnancy risks when the mother is 40 years old?

Query: Hello doctor, I am a 40 year old¬†female. I did nuchal translucency (NT) scan at 12 weeks and 1 day. The result reads NT 1.1 mm. Free beta hCG 25.9 ng/ml. PAPP-A 0.53. My sugar levels and BP are normal. I am taking Aspirin and Enoxaparin every day. Kindly tell me about my risks.  Read Full »

Dr. Balakrishnan. R

Answer: Hello, Welcome to How are you doing? I see nothing for you to worry about. Let me explain. Here age is the only factor, but this is only a relative term. In the general population, the risk of genetic problems is high after 40 years, and we tend to screen all the pregnant ladies around ...  Read Full »

What does PAPP-A screen test of 1.9 and hCG level of 65.6 indicate?

Query: Hi doctor, My wife has done a PAPP-A screen test and results are 1.9 and hCG level 65.6. She is 12 weeks pregnant. Please advise regarding the same. Thank you.  Read Full »

Dr. Sameer Kumar

Answer: Hello, Welcome to You need to attach the complete report issued by the laboratory. Important thing is the graph and the MoM (multiple of the median) values which have been calculated as per the gestational age. The risk is calculated accordingly. In case of Down's syndrome...  Read Full »

What does my double marker blood test indicate?

Query: Hi doctor, I am 12 weeks 5 days pregnant. I got my NT scan and double marker blood test results. NT value 1.1 mm, free b-hCG 1.52 MOM, PAPP-A 0.37 MOM, trisomy 21+NT risk 1:1132, trisomy 21 1:169, trisomy 13/18+NT. In urine culture, there is no significant growth observed after 48 hours. I am curre...  Read Full »

Dr. Jimesh H. Mavani

Answer: Hello, Welcome to I have seen the report completely (attachment removed to protect patient identity). Your report is normal and there is no need to worry. If you want a detailed explanation about the report, then here you go. There are some genetic syndromes, which are happening worl...  Read Full »

Is my dual test of pregnancy normal?

Query: Hi doctor, I just did a dual test. I am worried right now, please help. Gestational age is 12 weeks and 6 days, crown-rump length 64.8 mm, nuchal translucency MoM 1.7 mm, nasal bone is seen, hCG, free beta 60.47, PAPP-A 6020. Method: ECLIA (fully automated electrochemiluminescence system). I have a...  Read Full »

Dr. Sree Gouri. S. R

Answer: Hi, Welcome to I can understand your concern. According to your test results (attachment removed to protect patient identity), negative factors are: PAPP-A levels are elevated. Beta hCG levels are low. Positive factors are your age is below 30 years and nuchal translucency is normal. ...  Read Full »

Is it normal for intestine to be not inside in 12 weeks fetus?

Query: Hello doctor, I am 12 weeks one day pregnant. I went in for my NT scan today and they said it has possible gastroschisis and I am honestly just so worried. I have a checkup in the next two weeks but I am just curious to know if it could be normal that the intestines still are not inside the fetus? ...  Read Full »

Dr. Uzma Arqam

Answer: Hi, Welcome to Normally intestine is outside body of the fetus from 6 to 10 weeks of gestation is known as an intestinal hernia. Around 11 weeks it should be inside the body of the fetus. If you have been irregular periods there could be a discrepancy of dates between the scan and you...  Read Full »

What is the risk of trisomy 21 from my NT scan and double marker test?

Query: Hi doctor, I had an NT scan and a double marker test at 12 weeks and five days of pregnancy. The report is as follows. Maternal serum screen 2: Dual test. (CLIA) HCG, Free Beta 69.00 ng/mL equivalent to 1.81 Corr.MOM's PAPP-A 1.40 mIU/mL equivalent to 0.36 Corr.MOM's Disorder screen posit...  Read Full »

Dr. Deepti Verma

Answer: Hello, Welcome to I have gone through your question and understand the concerns. I have reviewed the report. It shows an increased risk in the first-trimester screening. You should go for amniocentesis at 16 weeks gestation to rule out any chromosomal anomalies in the fetus. Hope y...  Read Full »

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