Is it tough to conceive with PCOS/PMOS and HbE traits?

Question

Hello doctor,

I have PCOS/PMOS, and my blood report states hemoglobin is 10.3 g/dl, HbaO 6.2 b% HbA2 89.9 %, and HbF 3.6 %. My partner has hemoglobin 14 g/dl, HbaO 65.3 %, Hba2 33.4 5, and HbF 1.3 %, suggestive of the HbE trait.

Are there any medical complications for us?
Are we planning to go for family planning?
What necessary precaution is to be taken in the future?

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and understand your concern.

You are having Hb (hemoglobin) E disease, and your partner has HB E Trait; hence, in the future child, there is a 50 % chance of the child having a trait or it can be a disease phenomenon. Hb E usually does not lead to severe hemolytic reaction and usually does not need a regular blood transfusion like that of thalassemia major. Hb E disease leads are usually intermittent in nature, and the patient has mild anemia with splenomegaly sometimes.

Folic acid is usually prescribed to treat a deficiency that can occur in such conditions. Hence, you are given folic acid as well. Hence, no extra workup can be done here, as HB E is usually not a major hemolytic disease as compared to thalassemia, in my opinion.

If you have PCOS (polycystic ovary syndrome)/PMOS (polyendocrine metabolic ovarian syndrome), you cannot conceive, which means infertility is present, and hormonal pills, Clomiphene, and Leuprolide drugs can be prescribed as needed.

Consult a gynecologist for examination and further counseling if needed.

I hope I have answered all your questions.

Revert for any doubts.

Thank you.