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How to treat persistent pinworm infestation that is resistant to medications?

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Published At February 25, 2024
Reviewed AtFebruary 25, 2024

Patient's Query

Hello doctor,

I have been dealing with pinworms for the past 18 months, and they appear to be resistant to various anthelmintic medications. The infestation was confirmed through a paddle test using microscopy, and it started after visiting Mexico and being in contact with water and children.

I have tried several treatments, including Pyrantel, Albendazole, Mebendazole, Ivermectin, and herbal remedies, but none have fully resolved my symptoms. I have been meticulous about hygiene, constantly cleaning linens, and ensuring everyone in the house is treated. Even when I took a combination of Pyrantel, Albendazole, and Ivermectin daily during a solo trip for a week, the relief was only temporary (24-48 hours, if that) before the symptoms returned. I have also started experiencing oral candidiasis, which I believe could be related to the pinworms modulating my immune system. Despite my efforts to maintain a healthy lifestyle and diet, the pinworms persist. My blood tests, including eosinophil levels and A1c, are normal, and I do not have HIV or any immune diseases.

I am concerned that I might be experiencing T-cell exhaustion, and I' am wondering if alternative medicine could help kickstart my immune system. Interestingly, when my fiancée gets infected with pinworms, the medication works for her, but it seems ineffective for me, possibly due to the prolonged presence of the parasites in my body.

I am still waiting for my doctor's appointment. Please help.

Thank you.

Hello,

Welcome to icliniq.com.

Thank you for reaching out with your concerns.

Pinworm infestations, or enterobiasis, can often lead to recurrent reinfection, emphasizing the importance of treating the entire family to prevent recurrence. It is recommended to administer two doses of medication, two weeks apart, especially as young pinworms may exhibit resistance to treatment. All family members, whether symptomatic or not, should undergo treatment to prevent reinfection. Complications of pinworms may include superficial bacterial infections at scratching sites due to intense perianal pruritus. Also, non-intestinal pinworm infections have been reported in various organs. Eradicating pinworms from living environments can be challenging, requiring long-term surveillance.

You also seem to have an Epstein-Barr virus (EBV) infection, commonly known as infectious mononucleosis. Considering your recent travel exposure to Mexico, it is essential to address both concerns comprehensively. I would suggest the following treatment:

  1. For pinworms, consider a combination of anthelminthic drugs such as Ivermectin and Albendazole for a 3-day course, repeated after two weeks.
  2. Antiviral drugs should be considered for EBV infection.
  3. Pinworm symptoms can be managed with Paracetamol for fever and antihistamines for itching.
  4. Consult with your doctor to discuss and initiate this comprehensive approach to address both concerns effectively.

    If you have any further questions or need additional guidance, feel free to ask.

    Thank you.

Treatment plan

For pinworm infection 1. Tab Ivermectin 12 mg 1 tablet once daily for 3 days. 2. Tab Albendazole 400mg once daily for 4 days, followed by repeat the same dose after 2 weeks For Epstein Barr virus infection ( started after 2-3 days of 1st pinworm regimen) 3. Tab Valgancyclovir 800mg once daily for 8 weeks Tab Levocetirizine 5mg 1 tablet once daily for 7 days Tab Paracetamol (Acetaminophen) 500 mg 1-2 tablets SOS on body temparature > 100F.

Preventive measures

Treating other family members and contacts.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Shubadeep Debabrata Sinha
Dr. Shubadeep Debabrata Sinha

Infectious Diseases

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