What are the symptoms of overdose of Podophyllin?

Question

Hi doctor,

I treated some HPV genital warts using cryogenic therapy, followed by applying a liberal amount of Podophyllin, which I left on overnight. Sometimes, during sleep, I became very ill and agitated, had the chills, and could not get warm, and when I got up, I was very weak and lethargic, had no appetite, nausea and diarrhea, and swollen throat. I thought it was influenza since the virus is currently being transmitted locally.

However, upon further reading, the symptoms I am experiencing are the textbook overdose of Podophyllin. It has been about 8+ hours, and the symptoms have not gotten better or worse. I washed off the affected area with soap and water with the morning shower. Is there anything else I should do to treat the symptoms, and how much longer are they expected to continue? Please help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

I read your query and can understand your concern.

Based on your concern, it seems you are experiencing acute systemic toxicity, likely due to ligands in Podophyllin. Podophyllin is a substance used in treating certain medical conditions, but in some cases, it may lead to adverse reactions, including toxicity.

To address this, it is recommended that you seek immediate medical attention. A general physician can provide the necessary treatment. A single dose of Pheniramine (Avil), either intravenously or intramuscularly, is typically administered to help counteract allergic reactions and manage symptoms. Additionally, a single dose of Dexamethasone also administered intravenously or intramuscularly, can help reduce inflammation and stabilize your condition.

It is important to consult a healthcare provider before taking these medications to ensure they are appropriate for your situation. The doses mentioned (half a teaspoon) should be prescribed and monitored by a medical professional to ensure proper administration and avoid complications.

Acute systemic toxicity requires prompt attention, and the physician will be able to adjust the treatment as necessary. Be sure to follow up with your healthcare provider for further advice and monitoring of your symptoms.

I hope this helps.

Thank you.

Answer 2

Hi,

Welcome back to icliniq.com.

Continue cryotherapy sessions once in three to four weeks until the warts disappear completely. It is very safe. Along with cryotherapy, start taking oral zinc supplements. This will boost immunity. For Podophyllin allergy, wash off the region completely once again and under physician supervision. Usually, here, we plan for IV fluids along with systemic charcoal treatment if required.

I hope this helps.

Kindly revert back in case of queries.

Thank you.