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What are the treatment options for high-grade prostate cancer?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I was recently diagnosed with intraductal carcinoma of the prostate following a biopsy, along with Gleason score of 4+4=8 disease. My urologist mentioned that this is an aggressive variant.

Should I consider genetic testing, and how might this influence my treatment options or prognosis? Are there specific therapies or approaches recommended for cases like mine? Please help.

Thank you.

Answered by Dr. Mona Kamal

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

A prostate cancer diagnosis (a condition where cancer cells form in the tissues of the prostate) can be overwhelming, often triggering a range of emotions and imagining both best- and worst-case scenarios.

To address this uncertainty, Prolaris testing and genetic testing (including genomic and germline testing) can provide valuable insights into your specific cancer. These tests help assess cancer behavior, determine how aggressive it is, and guide you and your doctor in selecting the most appropriate treatment plan.

Probable cause:

Gleason score 8 aggressive prostate cancer (a high-grade cancer that is more likely to grow and spread).

Investigations to consider:

Prolaris test: This test is recommended for men who are newly diagnosed, untreated, or on active surveillance. It evaluates cancer aggressiveness and helps determine the most effective treatment strategy.

Treatment plan:

  1. Radiotherapy: Using targeted radiation to kill cancer cells.
  2. Hormonal therapy: Reducing hormone levels to slow cancer growth.
  3. Surgery: Removing the prostate to eliminate the cancer.

Taking these steps can help manage prostate cancer with clarity and confidence.

I hope this helps.

Revert with the answer to assist further.

Thank you and take care.

Answered by Dr. Mona Kamal
Medically reviewed by iCliniq medical review team
Published At February 12, 2025
Reviewed At January 8, 2026

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

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