What causes persistent PSA increase despite medication?

Hi,

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I read your query and can understand your concern.

Lupron (Leuprolide acetate) is a synthetic hormone used to treat conditions like prostate cancer (a type of cancer that develops in the prostate, a small gland in men that produces semen), endometriosis (a condition where tissue similar to the lining of the uterus grows outside the uterus, causing pain), and uterine fibroids (non-cancerous tumors that form in the uterus).

It is classified as a gonadotropin-releasing hormone (GnRH) agonist, which works by inhibiting the secretion of gonadotropins (luteinizing hormone and follicle-stimulating hormone). By suppressing the release of these hormones, Lupron reduces the production of sex hormones like testosterone in men and estrogen in women.

The active ingredient in Lupron is Leuprolide acetate, a long-acting synthetic analog of GnRH. This drug works by binding to GnRH receptors in the pituitary gland, leading to an initial surge in hormone release followed by desensitization, which ultimately reduces hormone production.

Other ingredients in the formulation include Mannitol (a sugar alcohol used as a stabilizer), Lactic acid (used to adjust the pH), and Sodium hydroxide (used to balance acidity). These excipients ensure the stability and proper delivery of the drug during administration.

In prostate cancer treatment, Lupron lowers testosterone levels, which can help shrink tumors or slow the growth of cancer cells that depend on testosterone. It is administered through injections, typically given monthly, every three months, or every six months, depending on the prescribed regimen.

Prostate cancer treatments vary by stage, including active surveillance, surgery (radical prostatectomy), radiation therapy (external beam or brachytherapy), hormone therapy (androgen deprivation therapy), chemotherapy, immunotherapy, and targeted drug therapies.

I hope this helps.

Kindly revert so I can assist you further.

Thank you.