Can Naproxen replace Methotrexate for psoriatic arthritis?

Question

Hello Doctor,

I need some advice. I have psoriatic arthritis, and my doctor prescribed me Methotrexate (Trexall), but it caused side effects. I used it for 12 to 14 weeks, but I stopped taking it two months back. Currently, I am taking Naproxen 250 mg tablets three times a week, along with Lansoprazole. Are there any dangers of using Naproxen? Is it safe to take a few times a week for the long term? I have been using Naproxen on and off for years, typically one to two tablets a week.

Kindly suggest.

Answer 1

Hello,

Welcome to icliniq.com.

I am very sorry about your medical condition, and I am glad you are paying attention to changes in your body. Do not worry, I am here to take care of you. It seems you have been taking Naproxen regularly. Yes, NSAIDs (non-steroidal anti-inflammatory drugs) like Naproxen are associated with severe side effects, especially when used over long periods. One of the major risks is kidney damage, which can become permanent if these medications are taken for an extended time.

Other side effects may occur in addition to kidney issues, which is why long-term use of NSAIDs is generally discouraged. To avoid these risks, medications like Methotrexate are often prescribed as they are better suited for long-term use with fewer side effects. I recommend that you revisit your physician and consider restarting Methotrexate (disease-modifying anti-rheumatic drug). It is one of the best long-term treatments for conditions like psoriatic arthritis. If you continue to experience severe side effects with Methotrexate, alternative treatment options are available, and your doctor can discuss them with you.

I hope this helps.

Thank you.