Q. Is Zoloft safe for heart?

Answered by
Dr. Suresh Kumar G D
and medically reviewed by Dr.Nithila A
This is a premium question & answer published on May 15, 2019

Hello doctor,

I have anxiety disorder from the age of 15 (will be 35 by the end of this month). I started having frequent panic attacks and debilitating anxiety after my grandmother's death. Before all this, I had been on Paxil. Six months before, my doctor switched me to Zoloft 50 mg and increased to 100mg and 150mg in the following consecutive months.

I am very worried about the possible QTc prolongation and sudden cardiac death. I struggle daily to take Zoloft. I had three ECG. First one was taken before six months, the second one before a month and the third one in this month in which my QTc was 400 to 420. Is Zoloft safe? Will it cause me sudden cardiac death?



Welcome to

Zoloft (Sertraline) is an effective and safe SSRI (selective serotonin reuptake inhibitor) for managing anxiety disorder. Zoloft is generally considered a low risk for QTc (is an electrocardiogram representation of ventricular depolarization and repolarization) prolongation in healthy people. I can see that you had three ECGs in the last few months with QTc between 400 to 420 which is within normal limits.

Zoloft in traditional doses (up to 200 mg daily) usually does not cause any significant increase in QTc. You are only on 150 mg once daily. So highly unlikely to have an adverse reaction. Can I ask why you are particularly worried about QTc prolongation and sudden cardiac death? Do you have any relevant risk factor like a previous heart problem or family history of arrhythmias and heart problems? Were these repeat ECGs done for any specific reason or only because of your anxiety?

If you are otherwise healthy, Zoloft is generally safe. If you need any other medication for other reasons, remind your doctor that you are on Zoloft so that they can avoid prescribing medication that can potentially interact together. Also, street drugs are not advisable. Regarding your other query about Ativan (Lorazepam), you can continue gradually weaning till you are off completely. When reduced gradually chances of withdrawal effects are much lesser. It is good that you are stopping Ativan as it is not recommended for long term use.

I note that you are currently in therapy. It will help to address your longstanding anxiety and develop better psychological coping strategies. It is common to experience worsening of your symptoms when you lose a loved one. Hopefully, you will recover gradually from the loss. You can also try deep breathing techniques and progressive muscular relaxation for managing stress and anxiety.

I will also advise you to discuss your worry about QTc prolongation with your prescribing doctor. He will be able to monitor and advise you accordingly.

Thank you doctor,

My anxiety is over sudden death. I also work in the medical field that is not helpful at times. I worked in ICU where we monitored QTc often. So when I read Zoloft side effects of possible QTc prolonging, I fixated on that. I had the ECGs because I asked for them to look at my QTc. The last one was a month ago, and it was 400. As for Ativan how can I gradually taper it anymore? I am taking 0.125 mg every day for two weeks now, but I do not need it. I am just worried about having a withdrawal seizure.



Welcome back to

I can understand your excessive worry about QTc prolongation, and since you are working in ICU it is easy to get fixated on it (I sometimes feel that working in the medical field is like a double-edged sword). But as I mentioned earlier, in the absence of any relevant cardiac history personally or in the family, there is no need in getting repeated ECG's done. All your QTc readings so far have been within normal limits. There is no added risk in taking Sertraline at the prescribed doses.

Just to put your mind at ease regarding Sertraline, it is safe enough to be used in several cardiac patients when their depression or anxiety needs to be treated. Have you considered whether that this fixation on QTc prolongation and sudden death can be a part of health anxiety? I will recommend to discuss it with your prescribing doctor and therapist so that this can be explored further and if needed appropriate intervention to tackle high anxiety levels can be considered.

Regarding Ativan, you have already successfully tapered down to a shallow dose. Chances of any withdrawal symptoms are highly unlikely hereafter. You can continue taking 0.125 mg every other day for another couple of weeks and then stop if you are feeling comfortable.

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