Q. How to reduce the dosage of antidepressants?

Answered by
Dr. Parth N. Nagda
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Oct 09, 2022 and last reviewed on: Oct 13, 2022

Hello doctor.

I have been using certain medicines for the past 20 years. However, I want to quit some of them to heal my body from chemical abuse. I use tablet Valproate EG 500, tablet Wellbutrin XR 150 mg, tablet Escitalopram 15 mg, tablet Emconcor 2.5 mg, tablet Xanax Retard 0.5 mg, tablet Pantoprazole 20 mg, tablet Questran 4 grams, and tablet Diazepam 5 mg. Kindly suggest a revised schedule.

Thank you.



Welcome to

I understand your concern.

It is advised to taper the dosage only when you feel completely fine. Also, the medicines that were started last should be tapered off first and over four to six weeks for each reduced dosage. Initially, I suggest you continue with the tablets Valproate, Wellbutrin, Escitalopram, and Diazepam.

You can reduce the dosages in the following order:

  • Stop the tablet Xanax 0.5 mg, take 0.25 mg, or take half of 0.25 mg for four weeks, then take it on alternate days for two weeks, and then stop.
  • Then reduce Escitalopram to 10 mg for four weeks.
  • Then reduce the tablet Diazepam 5 mg to half for four weeks.
  • Then take the tablet Wellbutrin for four weeks and stop.
  • Then tablet Valproate 500 mg, to 400 mg, to 300 mg, to 200 mg, by reducing the doses every three weeks.
  • Then tablet Escitalopram 5 mg for four weeks.
  • Then tablet Diazepam 2.5 mg half for four weeks.
  • Then stop the tablet Valproate.
  • Then stop the tablet Diazepam.
  • Lastly, stop the tablet Escitalopram.

In addition, try to take a healthy diet, exercise regularly, and take multivitamin supplements.

I hope this helps.

Thank you.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
How should I discontinue tablet Escitalopram safely before getting dependant on the drug?

I have not experienced any side effects due to the medication ... Is it acceptable if I end up having to take Escitalopram lifelong as there are no side effects ... Recently, I stopped taking ...   Read full

Will quitting Topomax result in regaining of lost weight caused by Mirtazapine?

This helps in stabilizing the mood and supplements the antidepressants ...   Read full

I want to go off antidepressants but have trouble sleeping. What can I do?

I have no side effects at all from any of the drugs only the disturbance of sleep ... It is a good medication but it is not so effective like Benzodiazepine ... I ha...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Coronavirus Variant Arcturus: | Omicron XBB.1.16 Variant
Arcturus is an emerging variant of the Omicron virus that causes various symptoms and spreads rapidly across the world. ...  Read more»
Adrenaline Rush - Symptoms, Causes, Effects, and How to Control
Adrenaline is a hormone responsible for fight or flight response. It is also a neurotransmitter and medicine. It is also...  Read more»
Fatty Liver - Types, Symptoms, Stages, and Treatment
The liver is the largest gland in the body. Its primary function is to process the food and drinks we consume. and filte...  Read more»

Ask your health query to a doctor online?

Ask a Psychiatrist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.